目的 探討舒筋通絡(luò)顆粒聯(lián)合普瑞巴林膠囊治療神經(jīng)根型頸椎病的臨床療效。方法 選取吉林大學(xué)校醫(yī)院在2022年8月—2024年8月收治的神經(jīng)根型頸椎病患者共94例，按隨機(jī)數(shù)字表法分為對(duì)照組和治療組，每組47例。對(duì)照組服用普瑞巴林膠囊，1粒/次，2次/d。治療組在對(duì)照組基礎(chǔ)上口服舒筋通絡(luò)顆粒，1袋/次，3次/d。兩組患者持續(xù)治療1個(gè)月。比較兩組的治療效果、頸椎功能、疼痛程度、肌電圖指標(biāo)和血清指標(biāo)。結(jié)果 治療組的總有效率為93.62%，對(duì)照組的總有效率為80.85%，組間差異明顯（P＜0.05）。治療后，兩組頸椎功能障礙指數(shù)（NDI）評(píng)分、上肢和肩頸的數(shù)字疼痛強(qiáng)度量表（NRS）評(píng)分均顯著減小（P＜0.05）；治療組的NDI評(píng)分、上肢和肩頸的NRS評(píng)分均小于對(duì)照組（P＜0.05）。治療后，兩組尺神經(jīng)、正中神經(jīng)的F波傳導(dǎo)速度均顯著升高（P＜0.05）；治療組尺神經(jīng)、正中神經(jīng)的F波傳導(dǎo)速度高于對(duì)照組（P＜0.05）。治療后，兩組的血清腫瘤壞死因子-α（TNF-α）、白細(xì)胞介素-1β（IL-1β）、白細(xì)胞介素-18（IL-18）水平均降低（P＜0.05），治療組的血清TNF-α、IL-1β、IL-18水平更低（P＜0.05）。結(jié)論 舒筋通絡(luò)顆粒聯(lián)合普瑞巴林膠囊可提高神經(jīng)根型頸椎病的療效，改善頸椎功能和減輕疼痛程度，降低炎癥反應(yīng)，改善神經(jīng)傳遞速度。

Objective To explore the clinical efficacy of Shujin Tongluo Granules combined with Pregabalin Capsules in treatment of cervical spondylotic radiculopathy. Methods 94 Patients with cervical spondylotic radiculopathy admitted to Jilin University Hospital from August 2022 to August 2024 were divided into control group and treatment group using a random number table method, with 47 patients in each group. The control group patients took Pregabalin Capsules, one capsule each time twice daily. On the basis of the control group, patients in the treatment group were orally administered Shujin Tongluo Granules, 1 bag each time, 3 times daily. The efficacy, cervical spine function, pain level, electromyographic indicators, and serum indicators between two groups were compared. Results The total effective rate of the treatment group was 93.62%, while the total effective rate of the control group was 80.85%, with significant differences between the groups (P< 0.05). NDI scores and NRS in the upper limbs and shoulder neck of both groups were decreased (P < 0.05), and NDI scores and NRS of the upper limbs and shoulder neck in the treatment group was lower than those of the control group (P< 0.05). After treatment, the F-wave conduction velocity of the ulnar nerve and median nerve in both groups were increased (P < 0.05), and these factors in the treatment group was higher than those in the control group (P < 0.05). The levels of TNF-α, IL-1β, and IL-18 in both groups were decreased (P< 0.05), and levels of TNF-α, IL-1β, and IL-18 in the treatment group were lower than those of the control group (P< 0.05). Conclusion The combination of Shujin Tongluo Granules and Pregabalin Capsules can improve the therapeutic effect of cervical spondylotic radiculopathy, further improve cervical function and reduce pain, reduce inflammatory response, improve nerve transmission speed.

R971