目的 探討治療小兒小兒急性感染性腹瀉，采用瀉速停顆粒聯(lián)合枯草桿菌二聯(lián)活菌治療的臨床療效。方法 選取2021年12月—2024年3月西北婦女兒童醫(yī)院收治的124例患兒，隨機數(shù)字法分為兩組(對照組和治療組)，每組62例。對照組枯草桿菌二聯(lián)活菌顆粒，1袋/次，每日2次。在對照組基礎(chǔ)上，治療組小兒瀉速停顆粒，6 g/次，每日3次。兩組用藥5 d觀察療效，比較兩組炎性因子水平、癥狀好轉(zhuǎn)時間、免疫因子水平及藥物不良反應(yīng)。結(jié)果 治療后，治療組總有效率（96.77%）高于對照組的總有效率（85.48%，P＜0.05）。治療后，與對照組比較，治療組嘔吐、發(fā)熱、腹痛、腹瀉好轉(zhuǎn)時間明顯縮短（P＜0.05）。治療后，兩組患兒血清免疫球蛋白G（IgG）、免疫球蛋白M（IgM）、免疫球蛋白A（IgA）指標均明顯升高（P＜0.05），且治療組免疫因子指標明顯高于對照組（P＜0.05）。治療后，兩組患兒淀粉樣蛋白A（SAA）、白細胞介素-6（IL-6）、內(nèi)皮素-1（ET-1）、白細胞介素-17（IL-17）水平比治療前低（P＜0.05），且治療組SAA、IL-6、ET-1、IL-17水平低于對照組（P＜0.05）。結(jié)論 枯草桿菌二聯(lián)活菌與小兒瀉速停顆粒協(xié)同治療，可改善明顯患兒感染性腹瀉癥狀，提高患兒免疫系統(tǒng)能力。

Objective To explore the clinical efficacy of Xiao’er Xiesuting Granules combined with Subtilis and Faecium Granules with, Live in treatment of acute in children. Methods Children (124 cases) with acute infectious diarrhea in Northwest Women and Children’s Hospital from December 2021 to March 2024 were divided into treatment (62 cases) the random number table method. Children in the were po with Combined Bacillus Subtilis and Faecium Granules with, Live, 1 bag/time. Children in the were po with Xiao’er Xiesuting Granules, 6 g/time. Children were treated for 5 d. After treatment, the clinical evaluations were evaluated, the symptom relief time and the immune and inflammatory factor levels in two before and after treatment were. Results After treatment, the effective rate (96.77%) was significantly higher (85.48%, P < 0.05). After treatment, the improvement time of vomiting, fever, abdominal pain, diarrhea in was significantly shortened (P < 0.05). the IgG, IgM and IgA in two increased (P < 0.05), and the immune factor were significantly higher (P < 0.05). After treatment, the levels of SAA, IL-6, ET-1 and IL-17 in two lower than treatment (P < 0.05), and the levels of inflammatory factors in the treatment lower than those in the control (P < 0.05). Conclusion The synergistic treatment of Combined Bacillus Subtilis and Faecium Granules with, Live combined with Xiao’er Xiesuting Granules can significantly improve the symptoms of infectious diarrhea in children, enhance the immune system ability of children.

R985

陜西省重點研發(fā)計劃項目（2019SF-064）