目的 探討在尼可地爾片基礎(chǔ)上聯(lián)合瓜蔞皮注射液治療穩(wěn)定型心絞痛的臨床效果。方法 選擇2023年1月—2023年12月在江南大學(xué)附屬醫(yī)院就診的84例穩(wěn)定型心絞痛患者，經(jīng)隨機(jī)數(shù)字表法將所有患者分為對(duì)照組和治療組，每組42例。對(duì)照組口服尼可地爾片，1片/次，3次/d。在此基礎(chǔ)上，治療組靜脈注射瓜蔞皮注射液，12 mL/次，1次/d，注射前用25%葡萄糖注射液250 mL稀釋。兩組患者治療1周。比較兩組患者治療效果、心絞痛發(fā)作情況、心功能指標(biāo)、血清心肌譜酶指標(biāo)、血清脂蛋白相關(guān)磷脂酶A2（Lp-PLA2）水平和血清炎癥因子。結(jié)果 治療組的總有效率（95.24%）顯著高于對(duì)照組總有效率（80.95%，P＜0.05）。治療后，兩組心絞痛發(fā)作次數(shù)和發(fā)作時(shí)間均降低（P＜0.05），治療組心絞痛發(fā)作次數(shù)和發(fā)作時(shí)間低于對(duì)照組（P＜0.05）。治療后，兩組左心室射血分?jǐn)?shù)（LVEF）升高，左心室舒張末期內(nèi)徑（LVEDD）降低（P＜0.05）；治療組LVEF高于對(duì)照組，LVEDD低于對(duì)照組（P＜0.05）。治療后，兩組血清N末端B型利鈉鈦前體（NT-proBNP）、Lp-PLA2、C反應(yīng)蛋白（CRP）、白細(xì)胞介素-6（IL-6）水平顯著降低（P＜0.05）；治療組血清NT-proBNP、Lp-PLA2、CRP、IL-6水平低于對(duì)照組（P＜0.05）。結(jié)論 穩(wěn)定型心絞痛患者經(jīng)瓜蔞皮注射液和尼可地爾片聯(lián)合治療可以提高治療效果，有效緩解患者的心絞痛發(fā)作情況，改善心功能指標(biāo)和心肌譜酶指標(biāo)，調(diào)節(jié)血清Lp-PLA2水平，降低炎癥反應(yīng)。

Objective To explore the clinical effect of Gualoupi Injection combined with Nicorandil Tablets in treatment of stable angina pectoris. Methods84 Patients with stable angina pectoris in Affiliated Hospital of Jiangnan University from January 2023 to December 2023 were divided into control group and treatment group using a random number table method, with 42 patients in each group. Patients in the control group took Nicorandil Tablets orally, 1 tablets/time, 3 times daily. On this basis, patients in the treatment group were iv administered with Gualoupi Injection, 12 mL/time, once daily, diluted with 250 mL 25% glucose injection. All patients were treated for one week. The treatment effect, angina pectoris attack, cardiac function indexes, serum myocardial spectrum enzyme index, serum lipoprotein-associated phospholipase A2 (Lp-PLA2) level, and serum inflammatory factors were compared between the two groups. Results The total effective rate (95.24%) of the treatment group was significantly higher than 80.95% of the control group (P < 0.05). The frequency and duration of angina attacks in both groups were decreased after treatment (P < 0.05), and the frequency and duration of angina attacks in treatment group was lower than those in the control group (P < 0.05). After treatment, LVEF in both groups was increased, but LVEDD was decreased (P < 0.05). After treatment, LVEF of the treatment group was higher than those in the control group, but LVEDD was lower than those in the control group (P< 0.05). After treatment, the levels of NT-proBNP, Lp-PLA2, CRP, and IL-6 in two groups were significantly decreased (P < 0.05), and compared with control group, the levels of serum indexes in the treatment group were lower (P< 0.05). Conclusion Gualoupi Injection combined with Nicorandil Tablets in treatment of stable angina pectoris can improve treatment efficacy, effectively alleviate angina attacks, improve cardiac function indicators and myocardial spectrum enzyme indicators, regulate serum Lp-PLA2 levels, and reduce inflammatory reactions.

R972

無錫市衛(wèi)健委科研項(xiàng)目（M202222）