目的 探討熱淋清顆粒聯(lián)合阿莫西林克拉維酸鉀治療兒童輸尿管支架管相關(guān)尿路感染的臨床療效。方法 選取2022年7月—2024年7月鄭州大學(xué)附屬兒童醫(yī)院收治的行腎積水或腎、輸尿管結(jié)石術(shù)后放置輸尿管支架的80例尿路感染患兒，依據(jù)隨機數(shù)字法分為對照組（40例）和治療組（40例）。對照組患兒口服阿莫西林克拉維酸鉀顆粒，3～9個月患兒20 mg/(kg∙d)，3次/d；9個月～2歲患兒20 mg/(kg∙d)，2次/d；2～6歲患兒，1袋/次，2次/d。在對照組基礎(chǔ)上，治療組患兒口服熱淋清顆粒，4 g/次，3次/d。兩組患兒用藥7 d。觀察兩組患兒臨床療效，比較治療前后兩組患兒癥狀緩解時間，及C反應(yīng)蛋白（CRP）、白細胞介素-6（IL-6）、降鈣素原（PCT）和腫瘤壞死因子-α（TNF-α）水平。結(jié)果 治療后，治療組總有效率（95.00%）明顯高于對照組（77.50%，P＜0.05）。治療后，與對照組對比，治療組退熱、尿菌轉(zhuǎn)陰時間、尿頻、尿痛、排尿困難緩解時間明顯縮短（P＜0.05）。治療后，兩組患者PCT、IL-6、TNF-α、CRP水平均明顯較低（P＜0.05），且以治療組治療后的變化更為顯著（P＜0.05）。結(jié)論 熱淋清顆粒與阿莫西林克拉維酸鉀協(xié)同治療兒童輸尿管支架管相關(guān)尿路感染，可提高臨床療效，縮短癥狀緩解時間，促使患兒機體的炎性因子減弱，使腎功能的恢復(fù)加快。

Objective To investigate the efficacy of Relinqing Granules combined with amoxicillin clavulanate potassium in treatment of ureteral stent-related urinary tract infection. Methods Children (80 cases) with ureteral stent-related urinary tract infection in Children’s Hospital Affiliated to Zhengzhou University from July 2022 to July 2024 were randomly divided into control (40 cases) and treatment (40 cases) group based on different treatments. Children in the control group were po administered with Amoxicillin and Clavulanate Potassium Granules, children aged 3 to 9 months 20 mg/(kg∙d), three times daily, children aged 9 months to 2 years 20 mg/(kg∙d), twice daily, children aged 2 to 6 years, 1 bag/time, twice daily. Children in the treatment group were po administered with Relinqing Granules based on the control group, 4 g/time, three times daily. Children in two groups were treated for 7 d. After treatment, the clinical evaluations were evaluated, the symptom relief time, and the PCT, IL-6, TNF-α and CRP in two groups before and after treatment were compared. Results After treatment, the effective rate in the treatment group (95.00%) was significantly higher than that in the control group (77.50%, P < 0.05). After treatment, compared with the control group, the time for fever reduction, urine bacteria to turn negative, and the time for relief of frequent frequency, dysuria, and dysuria in the treatment group were significantly shortened (P < 0.05). After treatment, the levels of PCT, IL-6, TNF-α, and CRP were significantly lower in two groups (P < 0.05), and the changes after treatment in the treatment group were more significant (P < 0.05). Conclusion The synergistic treatment of Relinqing Granules with amoxicillin and clavulanate potassium can improve clinical efficacy, shorten symptom relief time, reduce inflammatory factors, accelerate renal function recover.

R985;R983

河南省醫(yī)學(xué)科技攻關(guān)計劃聯(lián)合共建項目（2018020602）