目的 探討杜仲顆粒聯(lián)合硫酸鎂注射液治療妊娠期高血壓的臨床療效。方法 選取2023年6月—2024年10月在邢臺市中心醫(yī)院就診的妊娠期高血壓患者共106例，按隨機數(shù)字表法將患者分為對照組和治療組，每組53例。對照組靜脈滴注硫酸鎂注射液，首次劑量4 g，使用20 mL葡萄糖稀釋后5 min內(nèi)靜脈注射，然后以2 g/h靜脈滴注，1次/d，30 g/次。治療組在對照組基礎上口服杜仲顆粒，1袋/次，2次/d。兩組患者持續(xù)治療7 d。比較兩組的臨床療效、血壓指標、血流動力學指標和血清指標。結果 治療組的總有效率達96.23%，對照組的總有效率達83.02%，組間差異顯著（P＜0.05）。治療后，兩組的舒張壓、收縮壓、平均動脈壓均明顯降低（P＜0.05），治療組的舒張壓、收縮壓、平均動脈壓較對照組更低（P＜0.05）。治療后，兩組子宮螺旋動脈的收縮期峰值流速/舒張末期流速比值（S/D）、阻力指數(shù)（RI）、總血管阻力（TVR）均顯著降低（P＜0.05），且治療組子宮螺旋動脈的S/D、RI、TVR較對照組更低（P＜0.05）。治療后，兩組的血清Fibulin-3、血小板內(nèi)皮細胞黏附分子-1（PECAM-1）水平升高，血清可溶性Fms樣絡氨酸激酶-1（sFlt-1）水平降低（P＜0.05）；治療組的血清Fibulin-3、PECAM-1水平高于對照組，血清sFlt-1水平低于對照組（P＜0.05）。結論 杜仲顆粒聯(lián)合硫酸鎂注射液治療妊娠期高血壓具有較好的臨床療效，可有效降低血壓，改善血流動力學水平，減輕血管內(nèi)皮損傷。

Objective To explore the clinical efficacy of Duzhong Granules combined with Magnesium Sulfate Injection in treatment of hypertension during pregnancy. Methods A total of 106 patients with hypertension during pregnancy admitted in Xingtai Central Hospital from June 2023 to October 2024 were randomly divided into control group and treatment group using a random number table method, with 53 cases in each group. Patients in the control group received intravenous infusion of Magnesium Sulfate Injection, with an initial dose of 4 g, diluted with 20 mL glucose and injected intravenously within 5 min, followed by intravenous infusion at a rate of 2 g/h, once daily, 30 g/time. Patients in the treatment group took Duzhong Granules orally on the basis of the control group, 1 bag/time, twice daily. Patients in two groups were treated continuously for 7 d. The clinical efficacy, blood pressure indicators, hemodynamic indicators, and serum indicators were compared between two groups. ResultsAfter treatment, the total clinical effective rates in the control group the treatment group were 83.02% and 96.23%, respectively, and the difference between t two groups was statistically significant (P < 0.05). After treatment, the diastolic blood pressure, systolic blood pressure, and mean arterial pressure of the two groups were significantly decreased (P < 0.05), and the blood pressure indicators in treatment group was significantly lower than those in the control group (P < 0.05). S/D, RI, and TVR of the uterine spiral artery of the two groups were significantly reduced after treatment (P < 0.05), and hemodynamic indicators in the treatment group was lower than that of the control group after treatment (P < 0.05). After treatment, the levels of Fibulin-3 and PECAM-1 of the two groups were decreased, but the levels of sFlt-1 was lower than thaose before treatment (P < 0.05). The levels of Fibulin-3 and PECAM-1 of the treatment group were higher than those of the control group, but levels of sFlt-1 were lower than those of the control group after treatment (P < 0.05). Conclusion The combination of Duzhong Granules and Magnesium Sulfate Injection has good clinical efficacy in treatment of hypertension during pregnancy, which can effectively reduce blood pressure, improve hemodynamic levels, and alleviate endothelial damage.

R984

邢臺市重點研發(fā)計劃自籌項目（2023ZC065）