心肌缺血再灌注損傷在臨床上缺乏有效的治療方法。小檗堿是一種非堿性、季銨化的芐基異喹啉類(lèi)生物堿，具有多種藥理活性，可通過(guò)抑制細(xì)胞凋亡、抑制炎癥反應(yīng)、抑制氧化應(yīng)激、調(diào)節(jié)自噬來(lái)減輕心肌缺血再灌注損傷。綜述了小檗堿對(duì)心肌缺血再灌注損傷保護(hù)作用的研究進(jìn)展，為開(kāi)發(fā)心肌缺血再灌注損傷治療藥物提供參考。

There is a lack of effective treatment methods for myocardial ischemia-reperfusion injury in clinical practice. Berberine is a non alkaline, quaternized benzylisoquinoline alkaloid with various pharmacological activities, and can alleviate myocardial ischemia-reperfusion injury by inhibiting cell apoptosis, suppressing inflammatory response, inhibiting oxidative stress, and regulating autophagy. This article reviews the research progress on the protective effect of berberine on myocardial ischemia-reperfusion injury, providing reference for the development of therapeutic drugs for myocardial ischemia-reperfusion injury.

R972

國(guó)家自然科學(xué)基金資助項(xiàng)目（82100287）；中央高?；究蒲袠I(yè)務(wù)費(fèi)專(zhuān)項(xiàng)資金項(xiàng)目（2042022kf1091）；湖北省藥品（醫(yī)療器械）不良反應(yīng)監(jiān)測(cè)中心合作課題項(xiàng)目（20240123）；荊州市科技計(jì)劃項(xiàng)目（2023HC34）