[關鍵詞]
[摘要]
心肌缺血再灌注損傷在臨床上缺乏有效的治療方法。小檗堿是一種非堿性、季銨化的芐基異喹啉類生物堿,具有多種藥理活性,可通過抑制細胞凋亡、抑制炎癥反應、抑制氧化應激、調節(jié)自噬來減輕心肌缺血再灌注損傷。綜述了小檗堿對心肌缺血再灌注損傷保護作用的研究進展,為開發(fā)心肌缺血再灌注損傷治療藥物提供參考。
[Key word]
[Abstract]
There is a lack of effective treatment methods for myocardial ischemia-reperfusion injury in clinical practice. Berberine is a non alkaline, quaternized benzylisoquinoline alkaloid with various pharmacological activities, and can alleviate myocardial ischemia-reperfusion injury by inhibiting cell apoptosis, suppressing inflammatory response, inhibiting oxidative stress, and regulating autophagy. This article reviews the research progress on the protective effect of berberine on myocardial ischemia-reperfusion injury, providing reference for the development of therapeutic drugs for myocardial ischemia-reperfusion injury.
[中圖分類號]
R972
[基金項目]
國家自然科學基金資助項目(82100287);中央高?;究蒲袠I(yè)務費專項資金項目(2042022kf1091);湖北省藥品(醫(yī)療器械)不良反應監(jiān)測中心合作課題項目(20240123);荊州市科技計劃項目(2023HC34)