[關(guān)鍵詞]
[摘要]
心肌缺血再灌注損傷在臨床上缺乏有效的治療方法。小檗堿是一種非堿性、季銨化的芐基異喹啉類生物堿,具有多種藥理活性,可通過抑制細(xì)胞凋亡、抑制炎癥反應(yīng)、抑制氧化應(yīng)激、調(diào)節(jié)自噬來減輕心肌缺血再灌注損傷。綜述了小檗堿對(duì)心肌缺血再灌注損傷保護(hù)作用的研究進(jìn)展,為開發(fā)心肌缺血再灌注損傷治療藥物提供參考。
[Key word]
[Abstract]
There is a lack of effective treatment methods for myocardial ischemia-reperfusion injury in clinical practice. Berberine is a non alkaline, quaternized benzylisoquinoline alkaloid with various pharmacological activities, and can alleviate myocardial ischemia-reperfusion injury by inhibiting cell apoptosis, suppressing inflammatory response, inhibiting oxidative stress, and regulating autophagy. This article reviews the research progress on the protective effect of berberine on myocardial ischemia-reperfusion injury, providing reference for the development of therapeutic drugs for myocardial ischemia-reperfusion injury.
[中圖分類號(hào)]
R972
[基金項(xiàng)目]
國家自然科學(xué)基金資助項(xiàng)目(82100287);中央高?;究蒲袠I(yè)務(wù)費(fèi)專項(xiàng)資金項(xiàng)目(2042022kf1091);湖北省藥品(醫(yī)療器械)不良反應(yīng)監(jiān)測(cè)中心合作課題項(xiàng)目(20240123);荊州市科技計(jì)劃項(xiàng)目(2023HC34)