抑郁癥是威脅人類身心健康的重要神經(jīng)精神系統(tǒng)病變，發(fā)病機(jī)制復(fù)雜，與多種因素有關(guān)，目前以心理調(diào)節(jié)和藥物治療為主。黃精多糖是黃精中的活性成分，可通過(guò)調(diào)節(jié)單胺類神經(jīng)遞質(zhì)的分泌、抑制下丘腦-垂體-腎上腺軸過(guò)度激活、降低炎癥反應(yīng)、降低氧化應(yīng)激反應(yīng)、抑制神經(jīng)元細(xì)胞凋亡、增強(qiáng)神經(jīng)突觸重塑性、調(diào)節(jié)腸道菌群、抑制室旁核神經(jīng)元異常激活發(fā)揮抗抑郁作用?？偨Y(jié)了黃精多糖抗抑郁作用的研究進(jìn)展，為抑郁癥的藥物治療提供參考。

Depression is an important neurological and psychiatric disorder that threatens human physical and mental health. Its pathogenesis is complex and related to multiple factors. Currently, psychological regulation and medication treatment are the main methods. Polygonati Rhizoma polysaccharides are the active ingredients in Polygonati Rhizoma.Polygonati Rhizoma polysaccharides can regulate the secretion of monoamine neurotransmitters, inhibit excessive activation of the HPA axis, reduce inflammatory reactions, lower oxidative stress responses, inhibit neuronal cell apoptosis, enhance synaptic remodeling, regulate gut microbiota, and inhibit abnormal activation of paraventricular nucleus neurons, and exert antidepressant effects. This article summarizes the research progress on antidepressant effect of Polygonati Rhizoma polysaccharides, providing reference for the drug treatment of depression.

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