目的 探討金鳳丸聯(lián)合注射用絨促性素治療子宮內膜薄型不孕癥患者的臨床療效。方法 選取2022年4月—2023年4月在南陽市中心醫(yī)院確診并規(guī)范治療的110例子宮內膜薄型不孕癥患者作為研究對象，依據(jù)隨機數(shù)字表法分成治療組和對照組，每組各55例。對照組患者采用注射用絨促性素肌內注射治療，4 000 U/次，3 d/次；治療組在對照組用藥基礎上加用金鳳丸口服治療，10丸/次，2次/d。兩組均接受為期3個月的連續(xù)治療。對比兩組患者的妊娠情況、子宮內膜厚度、子宮內膜容積、月經癥狀量表中文版（MDQ）評分，子宮內膜搏動指數(shù)（PI）、血流阻力指數(shù)（RI）和收縮期峰值流速/舒張末期流速（S/D）水平。結果 治療后，治療組HCG陽性率、臨床妊娠率和活產率分別為63.64%、50.91%、82.14%，對照組HCG陽性率、臨床妊娠率和活產率分別為40.00%、30.91%、52.94%，治療組均明顯高于對照組（P＜0.05）。治療后，治療組子宮內膜薄型不孕癥患者子宮內膜厚度、子宮內膜容積均顯著增加，而MDQ評分顯著降低（P＜0.05）；治療后，治療組子宮內膜厚度、子宮內膜容積大于對照組，MDQ評分低于對照組（P＜0.05）。治療后，治療組子宮內膜薄型不孕癥患者PI、RI和S/D均明顯降低（P＜0.05）；治療后，治療組PI、RI和S/D明顯低于對照組（P＜0.05）。結論 金鳳丸聯(lián)合注射用絨促性素治療子宮內膜薄型不孕癥患者療效顯著，不僅能夠顯著提升患者妊娠率和活產率，而且還能夠改善患者子宮內膜容受性和血流指數(shù)，值得進行深入研究并加以推廣。

Objective To explore the clinical efficacy of Jinfeng Pills combined with chorionic gonadotrophin in treatment of endometrial thin infertility. Methods A total of 110 cases of patients with thin endometrial infertility diagnosed and standardized treatment in Nanyang Central Hospital from April 2022 to April 2023 were selected as research objects, and were divided into treatment group and control group according to random number table method, with 55 cases in each group. Patients in control group were im administered with Chorionic Gonadotrophin for Injection, 4 000 U/time, 3 d/time. Patients in the treatment group were po administered with Jinfeng Pills on the basis of control group, 10 pills/time, twice daily. Both groups received continuous treatment for 3 months. The pregnancy status, endometrial thickness, endometrial volume, MDQ score, endometrial PI, RI, and peak systolic flow velocity/end-diastolic flow velocity (S/D) levels of the two groups were compared. Results After treatment, the HCG positive rate, clinical pregnancy rate and live birth rate in the treatment group were 63.64%, 50.91%, and 82.14%, respectively, while the HCG positive rate, clinical pregnancy rate and live birth rate in the control group were 40.00%, 30.91%, and 52.94%, respectively, which were significantly higher in the treatment group than in the control group (P < 0.05). After treatment, endometrial thickness and endometrial volume of patients with thin endometrial infertility in the treatment group were significantly increased, but MDQ score was significantly decreased (P < 0.05). After treatment, the endometrial thickness and endometrial volume of the treatment group were higher than that of the control group, but the MDQ score was lower than that of the control group (P < 0.05). After treatment, PI, RI and S/D of patients with endometrial thin infertility in the treatment group were significantly decreased (P < 0.05). After treatment, PI, RI and S/D in the treatment group were significantly lower than those in the control group (P < 0.05). Conclusion Jinfeng Pills combined with chorionic gonadotrophin has significant curative effect on patients with endometrial thin infertility, and can not only significantly improve the pregnancy rate and live birth rate of patients, but also improve the endometrial tolerance and blood flow index of patients, which is worthy of further study and promotion.

R984

河南省醫(yī)學科技攻關省部共建青年項目（SBGJ202103107）