[關(guān)鍵詞]
[摘要]
神經(jīng)系統(tǒng)疾病是目前世界范圍內(nèi)的主流高發(fā)性疾病，有較高的致殘率和死亡率，形成原因多樣，臨床表型繁多，發(fā)病機(jī)制復(fù)雜，目前適用藥物仍無(wú)法對(duì)疾病的發(fā)展起到完全治療作用。迷迭香酸是一種多酚羥基化合物，可通過(guò)發(fā)揮抗氧化活性、改善突觸功能和緩解神經(jīng)炎癥防治腦缺血、抑郁癥、阿爾茨海默病、帕金森病、脊髓損傷等神經(jīng)系統(tǒng)疾病。綜述了迷迭香酸治療神經(jīng)系統(tǒng)疾病及其作用機(jī)制的研究進(jìn)展，為防治神經(jīng)系統(tǒng)疾病的藥物研發(fā)和臨床應(yīng)用提供參考。
[Key word]
[Abstract]
Nervous system diseases are currently the mainstream and highly prevalent diseases worldwide, with high disability and mortality rates, diverse causes, numerous clinical phenotypes, and complex pathogenesis. Currently, drugs still cannot fully treat the development of diseases. Rosmarinic acid is a polyphenolic hydroxy compound that can prevent and treat nervous system diseases such as cerebral ischemia, depression, Alzheimer's disease, Parkinson's disease, and spinal cord injury by exerting antioxidant activity, improving synaptic function, and alleviating neuroinflammation. This article reviews the research progress of rosmarinic acid in treatment of nervous system diseases and their mechanisms, providing reference for drug development and clinical application in prevention and treatment of nervous system diseases.
[中圖分類號(hào)]
R971
[基金項(xiàng)目]
福建省自然科學(xué)基金項(xiàng)目（2024J01129）；福建中醫(yī)藥大學(xué)基礎(chǔ)類學(xué)科科研提升計(jì)劃項(xiàng)目（XJC2022016）
