[關(guān)鍵詞]
[摘要]
骨質(zhì)疏松癥是一種全身性骨骼疾病，尋找安全有效的新型治療手段已成為骨質(zhì)疏松癥研究領(lǐng)域的熱點之一。槲皮素作為一種多酚類化合物，對骨質(zhì)疏松癥表現(xiàn)出積極的治療效果，可通過抗氧化作用、調(diào)節(jié)炎癥因子、具有雌激素樣作用、促進骨髓間充質(zhì)干細(xì)胞增殖分化、影響破骨細(xì)胞分化和相關(guān)信號通路、作用于細(xì)胞外基質(zhì)防治骨質(zhì)疏松癥。綜述了槲皮素防治骨質(zhì)疏松癥的作用機制研究進展，以推動槲皮素在骨質(zhì)疏松癥治療領(lǐng)域的應(yīng)用。
[Key word]
[Abstract]
Osteoporosis is a systemic bone disease, and finding safe and effective new treatment methods has become one of the hotspots in the field of osteoporosis research. Quercetin, as a polyphenolic compound, exhibits a positive therapeutic effect on osteoporosis. Quercetin can prevent and treat osteoporosis through antioxidant effects, regulation of inflammatory factors, estrogen like effects, promotion of proliferation and differentiation of bone marrow mesenchymal stem cells, influence of osteoclast differentiation and related signaling pathways, and action on extracellular matrix. This article reviews the research progress on mechanism of quercetin in preventing and treating osteoporosis, in order to promote its application in the field of osteoporosis treatment.
[中圖分類號]
R982
[基金項目]
陜西省重點研發(fā)計劃項目（2022SF-538）；陜西省中醫(yī)流派學(xué)派傳承工作室建設(shè)項目（陜中醫(yī)藥發(fā)[2018]40號）；咸陽市重點研發(fā)計劃（2021ZDYF-SF-0036）
