目的 探討冰黃膚樂軟膏聯(lián)合他克莫司軟膏治療肛周濕疹的臨床療效。方法 選取湖南中醫(yī)藥大學(xué)第二附屬醫(yī)院在2023年9月—2025年3月收治的肛周濕疹患者98例，按隨機(jī)數(shù)字表法將患者分為對照組和治療組，各組49例。對照組患者每日早晚涂抹他克莫司軟膏1次，1 FTU/次。治療組在對照組基礎(chǔ)上涂抹冰黃膚樂軟膏，3次/d，1 FTU/次，完成后按摩皮膚以促進(jìn)吸收。兩組患者共持續(xù)治療4周。對比兩組患者的治療效果、癥狀程度、肛周皮損面積、生活質(zhì)量、血清指標(biāo)。結(jié)果 治療組總有效率為93.88%，對照組的總有效率為79.59%，組間比較差異明顯（P＜0.05）。治療后，兩組的瘙癢程度評分、持續(xù)時間、發(fā)作頻率明顯降低（P＜0.05），且治療組的瘙癢程度評分、持續(xù)時間、發(fā)作頻率低于對照組（P＜0.05）。治療后，兩組患者的肛周皮損面積、皮膚生活質(zhì)量指數(shù)（DLQI）評分均降低（P＜0.05），且治療組的肛周皮損面積、DLQI評分低于對照組（P＜0.05）。治療后，兩組的血清白三烯B4（LTB4）、白細(xì)胞介素（IL）-23、IL-12p40水平均降低（P＜0.05），治療組的血清LTB4、IL-23、IL-12p40水平低于對照組（P＜0.05）。結(jié)論 冰黃膚樂軟膏聯(lián)合他克莫司軟膏可提高肛周濕疹的治療效果，減輕瘙癢癥狀，改善生活質(zhì)量，降低炎癥反應(yīng)。

Objective To explore the clinical efficacy of Binghuang Fule ointment combined with Tacrolimus Ointments in treatment of perianal eczema. Methods 98 Patients with perianal eczema admitted to the Second Affiliated Hospital of Hunan University of Chinese Medicine from September 2023 to March 2025 were selected and divided into control and treatment group using a random number table method, with 49 cases per group. Patients in the control group applied Tacrolimus Ointments in the morning and evening, once daily, at a dose of 1 FTU per application. On the basis of the control group, patients in the treatment group applied Binghuang Fule Ointments, 3 times daily, 1 FTU/time, and massaged the skin after completion to promote absorption. Patients received continuous treatment for 4 weeks. The treatment efficacy, symptom severity, perianal skin lesion area, quality of life, and serum indicators between two groups of the two groups were compared. Results The total effective rate of the treatment group was 93.88%, while the total effective rate of the control group was 79.59%, and there was a significant difference between the groups (P < 0.05). After treatment, the itch severity score, duration, and frequency in both groups were significantly reduced (P < 0.05), and the itch severity score, duration, and frequency of attacks in the treatment group were lower than those in the control group (P < 0.05). After treatment, the perianal skin lesion area and DLQI score of both groups of patients were decreased (P < 0.05), and the perianal skin lesion area and DLQI score of the treatment group were lower than those of the control group (P < 0.05). After treatment, the serum levels of LTB4, IL-23, and IL-12p40 in both groups were decreased (P < 0.05), and the serum levels of LTB4, IL-23, and IL-12p40 in the treatment group were lower than those in the control group (P < 0.05). Conclusion The combination of Binghuang Fule Ointments and Tacrolimus Ointments can improve the therapeutic effect of perianal eczema, further alleviate itching symptoms, improve quality of life, reduce inflammatory reactions.

R976

湖南省衛(wèi)生健康委科研計劃項目（D202214017139）