目的 觀察輕中度良性前列腺增生癥使用靈澤片和非那雄胺片治療的臨床療效。方法 選取石河子市人民醫(yī)院2021年7月—2024年1月收治的輕中度良性前列腺增生癥患者132例，根據(jù)雙色球法將患者分為對照組（66例）和治療組（66例）。對照組口服非那雄胺片，每次5 mg（1片），1次/d。治療組在對照組基礎(chǔ)上口服靈澤片，4片/次，3次/d。兩組均治療6周。對比兩組臨床療效、臨床癥狀、生活質(zhì)量、尿動力學(xué)指標(biāo)、血清炎癥因子和免疫功能。結(jié)果 對照組總有效率為77.63%，治療組總有效率為94.04%，組間比較差異顯著（P＜0.05）。兩組治療后國際前列腺癥狀評分（IPSS）、生活質(zhì)量指數(shù)（QOL）評分下降（P＜0.05），治療組治療后IPSS、QOL評分低于對照組（P＜0.05）。兩組治療后殘余尿量（PVR）、前列腺體積（PV）下降，最大尿流速（Q_max）升高（P＜0.05）；治療組治療后PVR、PV低于對照組，Q_max高于對照組（P＜0.05）。兩組治療后血清巨噬細(xì)胞趨化蛋白-1（MCP-1）、白細(xì)胞介素-6（IL-6）、巨噬細(xì)胞炎性蛋白2（MIP-2）、腫瘤壞死因子-α（TNF-α）水平下降（P＜0.05），治療組治療后血清MCP-1、IL-6、MIP-2、TNF-α水平低于對照組（P＜0.05）。治療后，兩組CD8⁺下降，CD3⁺、CD4⁺、CD4⁺/CD8⁺升高（P＜0.05）；治療組治療后CD8⁺低于對照組，CD3⁺、CD4⁺、CD4⁺/CD8⁺高于對照組（P＜0.05）。結(jié)論 靈澤片聯(lián)合非那雄胺片治療輕中度良性前列腺增生癥，可提高臨床療效，改善臨床癥狀，提高生活質(zhì)量，改善尿流動力學(xué)和血清炎癥因子水平，提高免疫功能。

Objective To observe the clinical efficacy of combine treatment with Lingze Tablets and Finasteride Tablets in treatment of mild to moderate benign prostatic hyperplasia. Methods 132 Patients with mild to moderate benign prostatic hyperplasia admitted to Shihezi People's Hospital from July 2021 to January 2024 were selected and divided into control group (66 cases) and treatment group (66 cases) according to the double chromosphere method. The control group took Finasteride Tablets orally, 5 mg (1 tablets) each time, once daily. The treatment group took Lingze Tablets orally on the basis of the control group, 4 tablets each time, 3 times daily. Both groups were treated for 6 weeks. The clinical efficacy, clinical symptoms, quality of life, urodynamic indicators, serum inflammatory factors, and immune function were compared between two groups. Results The total effective rate of the control group was 77.63%, the total effective rate of the treatment group was 94.04%, and the difference between the groups was significant (P < 0.05). After treatment, the IPSS and QOL scores in both groups were decreased (P < 0.05), and the IPSS and QOL scores of the treatment group were lower than those of the control group (P < 0.05). After treatment, the PVR and PVwere decreased in both groups, while the Q_max was increased (P < 0.05). The PVR and PV of the treatment group were lower than those of the control group after treatment, but the Q_max was higher than that of the control group (P < 0.05). After treatment, the serum levels of MCP-1, IL-6, MIP-2, and TNF-α were decreased in both groups (P < 0.05). The serum levels of MCP-1, IL-6, MIP-2, and TNF-α in the treatment group were lower than those in the control group (P < 0.05). After treatment, CD8⁺ were decreased in both groups, while CD3⁺, CD4⁺, and CD4⁺/CD8⁺ were increased (P < 0.05). After treatment, CD8⁺ in the treatment group was lower than that in the control group, while CD3⁺, CD4⁺, and CD4⁺/CD8⁺ were higher than those in the control group (P < 0.05). Conclusion The combination of Lingze Tablets and Finasteride Tablets in treatment of mild to moderate benign prostatic hyperplasia can improve clinical efficacy, alleviate clinical symptoms, enhance quality of life, improve urodynamics and serum inflammatory cytokine levels, and enhance immune function.

R983

石河子市科技計劃項目（2024ZDYL04）