目的 探討白芍總苷膠囊聯(lián)合硫酸羥氯喹片治療口腔扁平苔蘚的臨床療效。方法 將2023年3月—2025年2月在自貢市第一人民醫(yī)院就診的80例口腔扁平苔蘚患者納入研究，按隨機數(shù)字表法分為對照組和治療組，每組40例。對照組口服硫酸羥氯喹片，2次/d，2片/次。治療組在對照組基礎上口服白芍總苷膠囊，3次/d，2粒/次，兩組持續(xù)治療2個月。比較兩組的臨床療效、糜爛面積、疼痛程度、生活質(zhì)量、血清指標和淋巴細胞。結(jié)果 治療組總有效率為97.50%，對照組總有效率為82.50%，組間比較差異有統(tǒng)計學意義（P＜0.05）。兩組治療后的糜爛面積、視覺模擬量表（VAS）評分、口腔健康影響程度量表（OHIP）-14評分明顯降低（P＜0.05），且治療組的糜爛面積、VAS評分、OHIP-14評分低于對照組（P＜0.05）。兩組患者治療后的血清可溶性程序性死亡受體l（sPD-L1）、白細胞介素-12（IL-12）、白細胞介素-17（IL-17）水平顯著降低（P＜0.05），且治療組的血清sPD-L1、IL-12、IL-17水平較對照組更低（P＜0.05）。兩組治療后的Treg顯著升高，Th17、Th17/Treg顯著降低（P＜0.05）；治療組治療后的Treg高于對照組，Th17、Th17/Treg低于對照組（P＜0.05）。結(jié)論 白芍總苷膠囊聯(lián)合硫酸羥氯喹片可提高口腔扁平苔蘚的療效，降低疼痛程度和糜爛面積，減輕炎癥反應和調(diào)節(jié)免疫功能。

Objective To investigate the clinical efficacy of Total Glycosides of White Peony Capsules combined with Hydroxychloroquine Sulfate Tablets in treatment of oral lichen planus. Methods 80 Patients with oral lichen planus who received treatment in Zigong First People’s Hospital from March 2023 to February 2025 were included in the study and were divided into control group and treatment group using a random number table method, with 40 patients in each group. The control group took Hydroxychloroquine Sulfate Tablets orally, twice daily, two tablets each time. On the basis of the control group, patients in the treatment group took Total Glycosides of White Peony Capsules orally, three times daily, 2 capsules per time. Two groups were evaluated for treatment efficacy after completing 2 months of continuous treatment. The clinical efficacy, erosion area, pain level, quality of life, serum indicators, and lymphocytes were compared between two groups. Results The total effective rate of the treatment group was 97.50%, while the total effective rate of the control group was 82.50%, and the difference between the groups was statistically significant (P < 0.05). The erosion area, Visual Analog Scale (VAS) score, and Oral Health Impact Scale (OHIP) -14 score of the two groups after treatment were significantly decreased (P < 0.05), and the erosion area, VAS score, and OHIP-14 score of the treatment group were lower than those of the control group (P < 0.05). The serum levels of sPD-L1, IL-12, and IL-17 of two groups of patients after treatment were significantly reduced (P < 0.05), and the serum levels of sPD-L1, IL-12, and IL-17 in the treatment group were lower than those in the control group (P < 0.05). After treatment, the levels of Treg in both groups were significantly increased, while the levels of Th17 and Th17/Treg were significantly decreased (P < 0.05). The levels of Treg in the treatment group were higher than those in the control group after treatment, while Th17 and Th17/Treg levels were lower than those in the control group (P < 0.05). Conclusion The combination of Total Glycosides of White Peony Capsules and Hydroxychloroquine Sulfate Tablets can improve the efficacy of oral lichen planus, reduce pain and erosion area, alleviate inflammatory response, and regulate immune function.

R988.2

自貢市衛(wèi)生健康系統(tǒng)科研（24yb068）