結(jié)腸炎是常發(fā)生于青壯年的慢性特異性炎癥性病變，發(fā)病機(jī)制復(fù)雜。氧化苦參堿可通過減輕炎癥反應(yīng)、激活自噬通路、抑制鐵死亡、調(diào)節(jié)腸道菌群結(jié)構(gòu)、促進(jìn)新生血管形成、保護(hù)腸道黏膜屏障功能發(fā)揮治療結(jié)腸炎的作用?？偨Y(jié)了氧化苦參堿治療結(jié)腸炎的藥理作用研究進(jìn)展，為氧化苦參堿的臨床應(yīng)用提供參考。

Colitis is a chronic, specific inflammatory disease that often occurs in young adults, with a complex pathogenesis. Oxymatrine can treat colitis by reducing inflammation, activating autophagy pathways, inhibiting ferroptosis, regulating intestinal microbiota structure, promoting neovascularization, and protecting intestinal mucosal barrier function. This article summarizes the pharmacological research progress of oxymatrine in treatment of colitis, providing reference for the clinical application of oxymatrine.

R285.5;R975

重慶市科衛(wèi)聯(lián)合醫(yī)學(xué)科研項(xiàng)目（2019ZDXM042）