藥物再利用能極大地節(jié)約藥物發(fā)現(xiàn)過程中的時間和經(jīng)濟成本，可以有效降低失敗風(fēng)險。已經(jīng)出現(xiàn)耐藥性的抗生素類藥物左氧氟沙星、苯唑西林、多西環(huán)素、阿奇霉素通過藥物再利用挖掘，重新應(yīng)用在非感染性疾病的治療，如肺癌、阿爾茨海默病、瘧疾、新型冠狀病毒感染，有效提高此類藥物的應(yīng)用潛能。描述了抗生素類藥物的藥物再利用情況，分析其潛在風(fēng)險以及潛在風(fēng)險評估面臨的困難，為抗生素類藥物的藥物再利用提供新的思路和更加安全有效的研究方案。

Drug reuse can greatly save time and economic costs in the drug discovery process, and can effectively reduce the risk of failure. The antibiotic drugs levofloxacin, oxacillin, doxycycline and azithromycin that have emerged resistance are re-used in treatment of non-infectious diseases, such as lung cancer, Alzheimer's disease, malaria, and novel coronavirus infection, effectively improving the application potential of these drugs. This article describes the drug reuse of antibiotic drugs, analyzes their potential risks and the difficulties faced in risk assessment, and provides new ideas and safer and more effective strategies for drug reuse of antibiotic drugs.

R978.1