目的 探討有機陽離子轉(zhuǎn)運蛋白1（OCT1）（rs622342）和多藥及毒素外排轉(zhuǎn)運蛋白1（MATE1）（rs2289669）基因多態(tài)性對接受二甲雙胍治療的2型糖尿病患者血糖控制指標的影響。方法 采用橫斷面研究方法，所有確診為2型糖尿病的參與者接受鹽酸二甲雙胍片1～2 g/d治療至少3個月，記錄血糖控制水平、代謝指標，并測定OCT1和MATE1基因型，使用IBM SPSS Statistics for Windows V22.0統(tǒng)計分析不同基因型與患者血糖控制水平、代謝指標之間的相關(guān)性。結(jié)果 共納入191名2型糖尿病的患者。MATE1（rs2289669）AA/AG基因型攜帶者的空腹血糖（FPG）水平顯著低于GG基因型患者，高密度脂蛋白膽固醇（HDL-C）水平比GG型顯著升高。Logistics回歸結(jié)果發(fā)現(xiàn)，MATE1（rs2289669）對于FPG、身體質(zhì)量指數(shù)（BMI）和HDL-C有統(tǒng)計學意義。交互作用模型分析發(fā)現(xiàn)，在FPG中，同時擁有OCT1（rs622342）AA型和MATE1（rs228966）GG型基因的患者具有明顯的交互作用且為協(xié)同作用，無明顯相乘作用。結(jié)論 OCT1和MATE1基因多態(tài)性與接受二甲雙胍治療的2型糖尿病患者血糖控制有顯著關(guān)聯(lián)，在與FPG相關(guān)性方面存在協(xié)同效應，也與脂代謝和BMI有關(guān)。OCT1和MATE1基因多態(tài)性可能在二甲雙胍治療2型糖尿病患者血糖控制和代謝指標方面具有預測作用。

Objective To investigate the effect of organic cation transporter 1 (OCT1) (rs622342) and multidrug and toxin efflux transporter 1 (MATE1) (rs2289669) gene polymorphisms on blood glucose indicators in type 2 diabetes patients treated with metformin. Methods Using the cross-sectional study method, all participants diagnosed with type 2 diabetes were treated with Metformin Hydrochloride Tablets 1 — 2 g/d for at least three months, the blood glucose control level and metabolic indicators were recorded, and the OCT1 and MATE1 genotypes were determined. Statistical analyses were performed using IBM SPSS Statistics for Windows V22.0 to analyze the correlation between different genotypes and patients' blood glucose levels and metabolic indicators. Results A total of 191 patients with type 2 diabetes were included. The fasting blood glucose (FPG) level of MATE1 (rs2289669) AA/AG genotype carriers was significantly lower than that of GG genotype patients, but the high-density lipoprotein cholesterol (HDL-C) level was significantly higher than that of GG genotype patients. The logistics regression results showed that MATE1 (rs2289669) had statistical significance for FPG, body mass index (BMI), and HDL-C. The interaction model analysis showed that patients with both OCT1 (rs622342) AA and MATE1 (rs228966) GG genes in FPG exhibited significant interaction and synergistic effects, with no significant multiplicative effects. Conclusion The polymorphism of OCT1 and MATE1 genes is significantly associated with the blood glucose of type 2 diabetes patients treated with metformin. There is a synergistic effect in the correlation with FPG, and it is also associated with lipid metabolism and BMI levels. The polymorphism of OCT1 and MATE1 genes may have a predictive role in the blood glucose and metabolic indicators of type 2 diabetes patients treated with metformin.

R968;R977

山東省藥品臨床綜合評價項目（2024YZ002）；濟南市科技計劃項目（201602171）