目的 觀察蛤蚧定喘丸聯(lián)合復方硫酸沙丁胺醇氣霧劑治療老年支氣管哮喘穩(wěn)定期的臨床療效。方法 納入淄博一四八醫(yī)院2022年3月—2024年5月收治的94例老年支氣管哮喘患者，采用隨機數(shù)字表法將患者分為對照組（47例）和治療組（47例）。對照組接受復方硫酸沙丁胺醇氣霧劑治療，2撳/次，4次/d。治療組患者在對照組基礎(chǔ)上口服蛤蚧定喘丸，1丸/次，2次/d。兩組連續(xù)治療14 d。對比兩組臨床療效、臨床癥狀消失時間、哮喘控制情況、肺功能指標、血清炎性因子和免疫功能指標。結(jié)果 治療組的總有效率為95.74%，高于對照組的總有效率74.47%（P＜0.05）。治療組咳嗽、咯痰、氣短、喘息、肺內(nèi)哮鳴音消失時間短于對照組（P＜0.05）。兩組治療后哮喘控制測試（ACT）評分升高，哮喘控制問卷（ACQ-7）評分下降（P＜0.05），且治療后治療組的ACT評分高于對照組，ACQ-7評分低于對照組（P＜0.05）。兩組治療后用力肺活量（FVC）、第1秒用力呼氣容積（FEV1）、FEV1/FVC升高（P＜0.05），治療組患者的FVC、FEV1、FEV1/FVC高于對照組（P＜0.05）。兩組治療后白細胞介素-6（IL-6）、腫瘤壞死因子-α（TNF-α）、嗜酸性粒細胞計數(shù)（EOS）、轉(zhuǎn)化生長因子-β1（TGF-β1）顯著下降（P＜0.05），治療組IL-6、TNF-α、EOS、TGF-β1低于對照組（P＜0.05）。兩組治療后CD8⁺下降，CD3⁺、CD4⁺、CD4⁺/CD8⁺升高（P＜0.05），且治療組的免疫功能指標優(yōu)于對照組（P＜0.05）。結(jié)論 蛤蚧定喘丸聯(lián)合復方硫酸沙丁胺醇氣霧劑治療老年支氣管哮喘可縮短臨床癥狀緩解時間，有效控制哮喘，改善肺功能和免疫功能，減輕炎癥反應(yīng)。

Objective To observe clinical efficacy of Gejie Dingchuan Pills combine with Compound Salbutamol Sulfate Aerosol in treatment of elderly bronchial asthma in the stable stage. Methods A total of 94 elderly patients with bronchial asthma admitted to Zibo 148 Hospital from March 2022 to May 2024 were divided into control group (47 cases) and treatment group (47 cases) using random number table method. The control group received treatment with Compound Salbutamol Sulfate Aerosol, 2 sprays/time, 4 times daily. The treatment group took Gejie Dingchuan Pills orally on the basis of the control group, 1 pill per time, twice daily. Two groups were treated continuously for 14 d. The clinical efficacy, disappearance time of clinical symptoms, asthma control, lung function indicators, serum inflammatory factors, and immune function indicators were compared between two groups. Results The total effective rate of the treatment group was 95.74%, which was higher than the total effective rate of 74.47% in the control group (P < 0.05). The disappearance time of cough, sputum, shortness of breath, wheezing, and wheezing in the treatment group was shorter than that in the control group (P < 0.05). After treatment, ACT scores in two groups were increased, but ACQ-7 scores were decreased (P < 0.05). And the ACT scores of the treatment group were higher than those of the control group, while the ACQ-7 scores were lower than those of the control group (P < 0.05). After treatment, FVC, FEV1, and FEV1/FVC increased in two groups (P < 0.05). The FVC, FEV1, and FEV1/FVC in the treatment group were higher than those in the control group (P < 0.05). After treatment, the levels of IL-6, TNF-α, EOS, and TGF-β1 significantly decreased in two groups (P < 0.05). The levels of IL-6, TNF-α, EOS, and TGF-β 1 in the treatment group were lower than those in the control group (P < 0.05). After treatment, CD8⁺ in two groups decreased, while CD3⁺, CD4⁺, and CD4⁺/CD8⁺ increased (P < 0.05), and The immune function indicators of the treatment group were superior to those of the control group (P < 0.05). Conclusion The combination of Gejie Dingchuan Pills and Compound Salbutamol Sulfate Aerosol can shorten the clinical symptom relief time in elderly patients with bronchial asthma, effectively control asthma, improve lung function and immune function, and alleviate inflammatory reactions.

R974

國家衛(wèi)生健康委醫(yī)藥衛(wèi)生科技發(fā)展研究中心課題（W2022ZT642）