目的 探討骨松寶顆粒聯(lián)合唑來(lái)膦酸注射液治療股骨粗隆間骨折的效果。方法 將2022年3月—2025年2月在滄州市人民醫(yī)院就診的80例股骨粗隆間骨折患者作為研究對(duì)象，按隨機(jī)數(shù)字表法將患者分為對(duì)照組和治療組，每組各40例。對(duì)照組靜滴唑來(lái)膦酸注射液，每4周1次，每袋至少滴注15 min。治療組在對(duì)照組基礎(chǔ)上口服骨松寶顆粒，3次/d，1袋/次。4周為1個(gè)療程，兩組持續(xù)治療3個(gè)療程。比較兩組患者的治療效果、疼痛程度、關(guān)節(jié)功能、骨密度、血清指標(biāo)。結(jié)果 治療組、對(duì)照組的總有效率分別為97.50%、85.00%，組間比較差異有統(tǒng)計(jì)學(xué)意義（P＜0.05）。兩組治療后的視覺(jué)模擬評(píng)分法（VAS）評(píng)分明顯降低，髖關(guān)節(jié)功能（Harris）評(píng)分明顯升高（P＜0.05）；治療組治療后的VAS評(píng)分低于對(duì)照組，Harris評(píng)分高于對(duì)照組（P＜0.05）。兩組治療后的股骨粗隆、股骨頸骨密度均顯著升高（P＜0.05），且治療組的股骨粗隆、股骨頸骨密度高于對(duì)照組（P＜0.05）。兩組治療后的血清骨形態(tài)發(fā)生蛋白-2（BMP-2）水平升高，血清腫瘤壞死因子-α（TNF-α）、白細(xì)胞介素-10（IL-10）水平降低（P＜0.05）；治療組治療后的血清BMP-2水平高于對(duì)照組，血清TNF-α、IL-10水平低于對(duì)照組（P＜0.05）。結(jié)論 骨松寶顆粒聯(lián)合唑來(lái)膦酸注射液可提高股骨粗隆間骨折的治療效果，減輕疼痛程度，提高關(guān)節(jié)功能和骨密度，減輕炎癥反應(yīng)。

Objective To investigate the therapeutic effect of Gusongbao Granules combined with Zoledronic Acid Injection in treatment of intertrochanteric fractures of the femur. Methods A total of 80 patients with intertrochanteric fractures of the femur treated at Cangzhou People's Hospital from March 2022 to February 2025 were selected as the research subjects. The patients were randomly divided into control group and treatment group using the random number table method, with 40 cases in each group. The control group received intravenous Zoledronic Acid Injection once every 4 weeks for at least 15 min per bag. The treatment group took orally Gusongbao Granules on the basis of the control group, 3 times daily, 1 bag/time. Four weeks was one course of treatment, and two groups of patients receive continuous treatment for three courses. The treatment efficacy, pain level, joint function, bone density, and serum indicators were compared between two groups of patients. Results The total effective rates of the treatment group and the control group were 97.50% and 85.00%, respectively, and the difference was statistically significant between two groups (P < 0.05). After treatment, the visual analogue scale (VAS) scores were significantly decreased, but the hip joint function (Harris) scores were significantly increased in two groups (P < 0.05). The VAS score of the treatment group was lower than that of the control group after treatment, but the Harris score was higher than that of the control group (P < 0.05). The bone density of the femoral trochanter and femoral neck significantly increased in two groups after treatment (P < 0.05), and these indexes in the treatment group was higher than those in the control group (P < 0.05). After treatment, the serum levels of bone morphogenetic protein-2 (BMP-2) increased in two groups, while the serum levels of tumor necrosis factor-α (TNF-α) and interleukin-10 (IL-10) decreased (P < 0.05). The serum levels of BMP-2 in the treatment group were higher than those in the control group after treatment, while the serum levels of TNF-α and IL-10 were lower than those in the control group (P < 0.05). Conclusion The combination of Gusongbao Granules and Zoledronic Acid Injection can improve the therapeutic effect of intertrochanteric fractures of the femur, reduce pain, improve joint function and bone density, alleviate inflammatory reactions.

R982

河北省醫(yī)學(xué)科學(xué)研究課題計(jì)劃（20220320）