目的 研究樂孕寧顆粒聯(lián)合烯丙雌醇治療習慣性流產(chǎn)的臨床效果。方法 選取2022年3月—2023年11月西北婦女兒童醫(yī)院收治的習慣性流產(chǎn)患者204例，隨機分為對照組和治療組，每組各102例。對照組口服烯丙雌醇片，10 mg/次，1次/d。治療組在對照組基礎上口服樂孕寧顆粒，5 g/次，3次/d。兩組患者均治療至妊娠第5個月末。觀察兩組患者臨床療效，比較治療前后兩組患者癥狀緩解時間、性激素水平、血清炎癥因子水平和保胎成功率。結果 治療后，治療組總有效率高于對照組（90.20% vs 82.35%，P＜0.05）。治療組陰道出血、下腹墜脹和腰酸腹痛癥狀緩解時間均明顯短于對照組（P＜0.05）。治療后，兩組人絨毛膜促性腺激素β（β-HCG）、雌二醇（E₂）、孕酮（P）水平均較治療前顯著升高（P＜0.05），且治療組各項性激素指標水平高于對照組（P＜0.05）。治療后，兩組患者C反應蛋白（CRP）、白細胞介素-8（IL-8）、腫瘤壞死因子-α（TNF-α）水平較治療前顯著降低（P＜0.05），治療組各項炎癥指標水平低于對照組（P＜0.05）。治療后，治療組保胎成功率為92.16%，明顯高于對照組的81.37%，兩組比較差異具有統(tǒng)計學意義（P＜0.05）。結論 樂孕寧顆粒聯(lián)合烯丙雌醇對習慣性流產(chǎn)有良好應用，可促進癥狀消退，改善激素水平，降低血清炎癥因子水平，提高患者的保胎成功率。

Objective To study the clinical effect of Leyunning Granules combined with allylestrenol in treatment of habitual abortion. Methods Patients (204 cases) with habitual abortion in Northwest Women′s and Children′s Hospital from March 2022 to November 2023 were randomly divided into control and treatment group, and each group had 102 cases. Patients in the control group were po administered with Allylestrenol Tablets, 10 mg/time, once daily. Patients in the treatment group were po administered with Leyunning Granules on the basis of the control group, 5 g/time, three times daily. Patients in two groups were treated until the end of the 5th trimester. After treatment, the clinical evaluations were evaluated, and the symptom relief time, serum sex hormone levels, inflammatory indicators levels and rate of fetal protection in two groups before and after treatment were compared. Results After treatment, the total effective rate of the treatment group was higher than that of the control group (90.20% vs 82.35%, P < 0.05). The relief time of vaginal bleeding, lower abdominal distension and lumbago and abdominal pain symptoms in treatment group was significantly shorter than that in control group (P < 0.05). After treatment, the levels of β-HCG, E₂, and P in both groups were significantly increased compared with those before treatment (P < 0.05), and the levels of various sex hormone indicators in treatment group were higher than those in control group (P < 0.05). After treatment, the levels of CRP, IL-8, and TNF-α in both groups were significantly lower than those before treatment (P < 0.05), and the levels of various inflammatory indicators in treatment group were lower than those in control group (P < 0.05). After treatment, the success rate of maintaining pregnancy in treatment group was 92.16%, significantly higher than 81.37% in control group. The difference between the two groups was statistically significant (P< 0.05). Conclusion Leyunning Granules combined with Allylestrenol Tablets has good clinical efficacy in the treatment of habitual abortion, which can alleviate various symptoms, increase the level of sex hormones, reduce the level of serum inflammatory factors, improve the success rate of fetal protection.

R984

陜西省重點研發(fā)計劃項目（2021SF-040）