目的 觀察金花消痤丸聯(lián)合克林霉素甲硝唑搽劑治療玫瑰痤瘡的臨床療效。方法 納入衡水市人民醫(yī)院2022年4月—2024年2月收治的玫瑰痤瘡患者100例，采用隨機(jī)數(shù)字表法將患者分為對照組和治療組，各50例。對照組患處外用克林霉素甲硝唑搽劑，每日早晚各1次，待藥液干燥后全面部涂醫(yī)用愈膚生物膜。治療組在對照組的基礎(chǔ)上口服金花消痤丸，1袋/次，3次/d。兩組療程均為4周。比較兩組的臨床療效、臨床癥狀積分、皮膚生理指標(biāo)、生活質(zhì)量、血清因子。結(jié)果 治療組的總有效率為94.00%，高于對照組的總有效率76.00%（P＜0.05）。治療后，兩組潮紅斑評分、毛細(xì)血管擴(kuò)張評分、丘疹和膿皰評分下降（P＜0.05），且治療組潮紅斑評分、毛細(xì)血管擴(kuò)張評分、丘疹和膿皰評分低于對照組（P＜0.05）。治療后，兩組表皮水分流失量、皮膚油脂量下降，皮膚角質(zhì)層含水量升高（P＜0.05），且治療組表皮水分流失量、皮膚油脂量低于對照組，皮膚角質(zhì)層含水量高于對照組（P＜0.05）。治療后，兩組玫瑰痤瘡生活質(zhì)量量表（RosaQoL）評分下降（P＜0.05），且治療組RosaQoL評分低于對照組（P＜0.05）。治療后，兩組血清C反應(yīng)蛋白（CRP）、白細(xì)胞介素（IL）-37、IL-17A、IL-6、腫瘤壞死因子-α（TNF-α）水平下降（P＜0.05），治療組血清CRP、IL-37、IL-17A、IL-6、TNF-α水平低于對照組（P＜0.05）。結(jié)論 金花消痤丸聯(lián)合克林霉素甲硝唑搽劑治療玫瑰痤瘡可有效改善臨床癥狀，提高生活質(zhì)量，降低炎癥因子水平。

Objective To observe the clinical efficacy of Jinhua Xiaocuo Pills combine with Clindamycin Hydrochloride and Metronidazole Liniment in treatment of rosacea. Methods A total of 100 patients with rosacea admitted to Hengshui People’s Hospital from April 2022 to February 2024 were divided into control group and treatment group using a random number table method, with 50 patients in each group. The control group applied Clindamycin Hydrochloride and Metronidazole Liniment topically to the affected area, once in the morning and once in the evening. After the medicine was dried, the entire area was coated with a medical healing biofilm. The treatment group took Jinhua Xiaocuo Pills orally on the basis of the control group, 1 bag/time, 3 times daily. The treatment course for two groups was 4 weeks. The clinical efficacy, clinical symptom score, skin physiological index, quality of life, and serum factors were compared between two groups of patients. Results The total effective rate of the treatment group was 94.00%, which was higher than the total effective rate of 76.00% in the control group (P < 0.05). After treatment, the scores of erythema, telangiectasia, papules, and pustules in two groups decreased (P < 0.05), and the scores of erythema, telangiectasia, papules, and pustules in the treatment group were lower than those in the control group (P < 0.05). After treatment, the loss of epidermal water and the amount of skin oil decreased in two groups, while the moisture content of the stratum corneum increased (P < 0.05). Moreover, the loss of epidermal water and the amount of skin oil in the treatment group were lower than those in the control group, while the moisture content of the stratum corneum was higher than that in the control group (P < 0.05). After treatment, the RosaQoL scores of two groups decreased (P < 0.05), and the RosaQoL score of the treatment group was lower than that of the control group (P < 0.05). After treatment, the serum levels of C-reactive protein (CRP), interleukin-37 (IL-37), IL-17A, IL-6, and tumor necrosis factor-α (TNF-α) decreased in two groups (P < 0.05), and the serum levels of CRP, IL-37, IL-17A, IL-6, and TNF-α in the treatment group were lower than those in the control group (P < 0.05). Conclusion The combination of Jinhua Xiaocuo Pills combine with Clindamycin Hydrochloride and Metronidazole Liniment in treatment of rosacea can effectively improve clinical symptoms, enhance quality of life, and reduce levels of inflammatory factors.

R986

衡水市科技計劃項目（2021014078Z）