成骨細(xì)胞是骨代謝中主導(dǎo)骨形成的主要功能細(xì)胞，對骨骼的生長、骨平衡的維持至關(guān)重要。成骨細(xì)胞分化受多條信號通路的調(diào)控，如Wnt/β-連環(huán)蛋白、骨形態(tài)發(fā)生蛋白/Smad、絲裂原活化蛋白激酶、Hedgehog通路，這些通路的異常激活或抑制均可能導(dǎo)致骨形成失衡，而中藥成分可通過靶向調(diào)控這些信號通路的關(guān)鍵分子發(fā)揮促成骨效應(yīng)。綜述了中藥成分調(diào)控信號通路促進(jìn)成骨細(xì)胞分化的研究進(jìn)展，總結(jié)其作用機(jī)制和潛在應(yīng)用價(jià)值，為骨質(zhì)疏松癥等骨代謝疾病的藥物研發(fā)提供參考。

Osteoblasts are the main functional cells that dominate bone formation in bone metabolism and are crucial for bone growth and maintenance of bone balance. Osteoblast differentiation is regulated by multiple signaling pathways, such as Wnt/β-catenin, BMP/Smad, MAPK, and Hedgehog signaling pathway. Abnormal activation or inhibition of these signaling pathways may lead to imbalanced bone formation, and traditional Chinese medicine components can promote bone effects by targeting key molecules in these signaling pathways. This article reviews the research progress on the regulation of signaling pathways by traditional Chinese medicine components to promote osteoblast differentiation, summarizes its mechanism and potential application value, and provides reference for drug development of bone metabolism diseases such as osteoporosis.

R285.5

云南省社科聯(lián)-云南中醫(yī)藥大學(xué)聯(lián)合專項(xiàng)（LHZX202423）；云南省科技人才與平臺計(jì)劃（院士專家工作站）（202305AF150151）