子宮內(nèi)膜異位癥的發(fā)病機(jī)制復(fù)雜，臨床主要的治療目的為減輕臨床癥狀、限制病灶生長(zhǎng)。槲皮素具有多種藥理作用，可通過(guò)抑制異位細(xì)胞增殖、阻止內(nèi)異細(xì)胞侵襲和遷移、減輕氧化應(yīng)激反應(yīng)、抑制間質(zhì)纖維化、抑制新生血管形成、促進(jìn)異位病灶細(xì)胞凋亡、調(diào)節(jié)下丘腦–垂體–卵巢軸功能治療子宮內(nèi)膜異位癥?？偨Y(jié)了槲皮素治療子宮內(nèi)膜異位癥的藥理作用研究進(jìn)展，為槲皮素的臨床應(yīng)用提供參考。

The pathogenesis of endometriosis is complex, and the main clinical treatment goal is to alleviate clinical symptoms and limit lesion growth. Quercetin has multiple pharmacological effects, and can treat endometriosis by inhibiting ectopic cell proliferation, preventing invasion and migration of ectopic cells, reducing oxidative stress response, inhibiting interstitial fibrosis, inhibiting angiogenesis, promoting apoptosis of ectopic lesion cells, and regulating hypothalamic-pituitary-ovarian axis function. This article summarizes the pharmacological research progress of quercetin in treatment of endometriosis, providing a reference for the clinical application of quercetin.

R287.4

重慶市科衛(wèi)聯(lián)合醫(yī)學(xué)科研項(xiàng)目（2019MSXM007）