目的 比較替吉奧與卡培他濱分別聯(lián)合多西他賽（TXT）治療進(jìn)展期胃癌的有效性、安全性及經(jīng)濟(jì)效果。方法 試驗(yàn)分A、B兩組，第1天均給予多西他賽75 mg/m²，靜脈滴注2 h；第1～14天，A組每天給予卡培他濱2 000 mg/m²， B組每天給予替吉奧膠囊60 mg/m²，兩組給藥均分為兩等份于早晚餐后0.5 h用水吞服，服用2周后休息1周，3周為1個(gè)周期，至少完成2個(gè)周期，最多完成6個(gè)周期后評(píng)價(jià)。結(jié)果 50例均可評(píng)價(jià)療效。A、B兩組的總有效率分別為46.21%和50.00%，疾病控制率為76.92%和75.00%（P＞0.05），平均成本分別為17 158.90元和10 094.37元。成本–效果比分別為371.81和201.89。兩組不良反應(yīng)主要包括骨髓抑制、惡心嘔吐、腹瀉、口腔黏膜炎和手足綜合征等，以1～2級(jí)為主，均可耐受。結(jié)論 兩組治療晚期胃癌的療效相當(dāng)，不良反應(yīng)均可耐受，但B組成本–效果明顯低于A組，因此替吉奧聯(lián)合多西他賽治療進(jìn)展期胃癌方法更優(yōu)，值得臨床推廣。

Objective To compare the effectivity, safety, and economic effects on advanced gastric cancer of Gio Capsule and capecitabine combined with docetaxel (TXT) respectively. Methods Patients were divided into groups A and B: On day 1, TXT (75 mg/m²) was iv administrated for 2 h; On days 1―14, group A was administrated with capecitatime (2 000 mg/m²) and group B with Gio Capsule (60 mg/m²). The doses were divided into two equal parts and swallowed with water in half-hour after meal in the morning and evening. The administration was for two weeks and then one week rest, every three weeks as a cycle. The course of chemotherapy was repeated for three to four cycles. Results Fifty cases were available. The total effective rates of groups A and B were 46.26% and 50.00%, respectively; The disease control rates were 76.92% and 75.00% (P > 0.05); Average cost was 12 407.98 and 10 846.72 Yuan. The cost-effectiveness rates (C/E) were 268.86 and 195.24, respectively. The major adverse drug reactions of the two groups were bone marrow suppression, nausea, vomiting, diarrhea, oral mucositis, and hand foot syndrome, which were of grades 1―2 and could be tolerated. Conclusion Two groups have similar effects in the treatment of advanced gastric cancer and the adverse reactions could be tolerated. But the C/E of group B is significantly lower than that of group A, as a result Gio Capsule combined with TXT is better for treating advanced gastric cancer.