目的：利用 GC / MS 技術(shù)建立測定口服舒心平軟膠囊后人血漿樣品中龍腦含量的方法。方法：采用 HP-WAX 石英毛細管柱（30 m × 0.25 mm × 0.25 μm），柱溫為 150 ℃，保持 5.5 min，以 40 ℃/min 的速率升至 190℃，保持 1 min。以氦氣為載氣，分流比為 5∶1，掃描方式選擇離子檢測（SIM），定量龍腦為m/z 95，定量內(nèi)標(biāo)（萘）為m/z 128。結(jié)果：龍腦和內(nèi)標(biāo)的保留時間分別為 4.56 min 和 5.31 min，龍腦在 5～1 000 ng/mL線性關(guān)系良好（r = 0.999 3），高、中、低 3 個濃度的樣品提取回收率均在 80 % 以上。結(jié)論：本測定方法可以快速簡便地定量分析人血漿樣品中的龍腦含量，有較高的靈敏度和較好的重現(xiàn)性，可以滿足舒心平的人體藥代動力學(xué)研究。

Objective: A sensitive and selective GC/MS method has been developed to determine the level of borneol in human plasma after po ShuXinPing Capsules. Methods: The quantitative analysis were carried out by using a HP-WAX silica capillary column（30 m × 0.25 mm × 0.25 μm）. The column was maintained at 150 ℃ for 5.5 min, then the temperature was increased to 190 ℃ which was kept for 1 min at the speed of 40 ℃/min. Helium was applied as carrier gas. The splitting-ratio was 5∶1. Selective ion monitoring（SIM）was utilized for quantitation of the molecules. Borneol was monitored for the ion of m/z 95, while ions of m/z 128 were selected for naphthalene（IS）. Results: The reserve time of borneol and IS was 4.56 min and 5.31 min, respectively. Linearity was tested ranging from 5 to 1 000 ng/mL（r = 0.999 3）. The average recoveries were 86.7 %, 81.9 % and 83.9 % at the concentrations of 10, 50 and 500 ng/mL. Conclusion: The method is simple, fast, high sensitive and repeatability for quantitative analysis of borneol in human plasma, which was applied in pharmacokinetics research of ShuXinPing Capsule.