目的：觀察大鼠連續(xù)靜脈/腹腔交替注射刺五加注射液產(chǎn)生的毒性反應(yīng)與靶器官損害的可逆性。方法：通過(guò)血液學(xué)、血液生物化學(xué)和病理組織學(xué)檢查，觀察注射刺五加注射液對(duì)大鼠的毒性反應(yīng)及程度。結(jié)果：連續(xù)靜脈/腹腔交替注射刺五加注射液4 周，動(dòng)物全部存活，高、低劑量組動(dòng)物未見(jiàn)明顯毒性反應(yīng)，停藥后各劑量組均未見(jiàn)遲緩性毒性發(fā)生。結(jié)論：刺五加注射液連續(xù)靜脈/腹腔交替注射對(duì)大鼠體重增長(zhǎng)率、各主要器官臟器系數(shù)、血細(xì)胞和血液生化指標(biāo)均無(wú)顯著影響，病理組織學(xué)檢查亦未見(jiàn)毒性病理改變，停藥后2周亦未見(jiàn)延遲毒性，即刺五加注射液對(duì)大鼠無(wú)明顯毒性。

Objective: To observe the toxic reactions and reversibility of target organ damage by alternatively continuous iv and ip injection of Ciwujia Injection (Acanthopanax Injection) in rats. Methods: The degree of toxicity was observed in rats by injection of Ciwujia Injection with hematological, blood biochemical and histopathological methods. Results: All animals survived after continuous iv and ip injection of Ciwujia Injection for 4 weeks. High-dose and low-dose group animals had no significant toxicity and no delayed toxicity occurred after treatment with various doses. Conclusion: Body weight growth rate, organ coefficient of major organs, blood cells and blood biochemical parameters had no significant effect after alternatively continuous iv and ip injection of Ciwujia Injection in rats, histopathological examination are also no toxic pathological changes, no sign of delayed toxicity was examined after three weeks of drug withdrawal, that is, Ciwujia Injection had no significant toxicity.