目的：觀察大鼠連續(xù)靜脈/腹腔交替注射刺五加注射液產(chǎn)生的毒性反應與靶器官損害的可逆性。方法：通過血液學、血液生物化學和病理組織學檢查，觀察注射刺五加注射液對大鼠的毒性反應及程度。結(jié)果：連續(xù)靜脈/腹腔交替注射刺五加注射液4 周，動物全部存活，高、低劑量組動物未見明顯毒性反應，停藥后各劑量組均未見遲緩性毒性發(fā)生。結(jié)論：刺五加注射液連續(xù)靜脈/腹腔交替注射對大鼠體重增長率、各主要器官臟器系數(shù)、血細胞和血液生化指標均無顯著影響，病理組織學檢查亦未見毒性病理改變，停藥后2周亦未見延遲毒性，即刺五加注射液對大鼠無明顯毒性。

Objective: To observe the toxic reactions and reversibility of target organ damage by alternatively continuous iv and ip injection of Ciwujia Injection (Acanthopanax Injection) in rats. Methods: The degree of toxicity was observed in rats by injection of Ciwujia Injection with hematological, blood biochemical and histopathological methods. Results: All animals survived after continuous iv and ip injection of Ciwujia Injection for 4 weeks. High-dose and low-dose group animals had no significant toxicity and no delayed toxicity occurred after treatment with various doses. Conclusion: Body weight growth rate, organ coefficient of major organs, blood cells and blood biochemical parameters had no significant effect after alternatively continuous iv and ip injection of Ciwujia Injection in rats, histopathological examination are also no toxic pathological changes, no sign of delayed toxicity was examined after three weeks of drug withdrawal, that is, Ciwujia Injection had no significant toxicity.