24/MPC,C max /MPC 作為防止耐藥突變的預(yù)測(cè)指標(biāo)優(yōu)于AUC24/MIC。根據(jù)防耐藥突變理論選擇應(yīng)用抗感染藥物為延緩耐藥提出了新的策略。;To review the recent research of mutant prevention concentration (MPC) and the latest progress. Reviews related to MPC in the recent ten years were reported in this paper. All these in vitro and in vivo studies indicated that MPC and mutant selective window (MSW) were new indexes to evaluate the antimicrobial resistance. During application of antibiotics, narrowing or closing the MSW, restraining and deplaying the bacteria-resistant mutant should try to be made. Besides selecting an ideal drug and optimizing the proper dosage, the combination therapy may be a safe and effective way to inhibit the development of resistance. AUC24/MPC is more appropriate than AUC24/MIC for predicting the restriction of resistant mutant emergence. It offers the ideal and new strategy for restricting resistant mutants and delaying antimicrobial resistance."/>

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首頁(yè) > 過(guò)刊瀏覽>2010年第33卷第1期 >2010,33(1):13-18. DOI:10.7501/j.issn.0253-6376.[year].1.[sequence]
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抗菌藥物防細(xì)菌耐藥突變濃度理論及研究進(jìn)展

Advances in studies on mutant prevention concentration rationale for antimicrobial agents

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