生殖毒性試驗(yàn)是毒理學(xué)試驗(yàn)中較為復(fù)雜和繁瑣、技術(shù)要求較高的試驗(yàn)。現(xiàn)從實(shí)驗(yàn)技術(shù)人員資質(zhì)要求、試驗(yàn)前準(zhǔn)備、試驗(yàn)期觀察、試驗(yàn)記錄、供試品、對(duì)照品的配制和給予、親本動(dòng)物的剖殺和檢查、與專題負(fù)責(zé)人溝通確認(rèn)等方面介紹作為技術(shù)人員如何做好安全性評(píng)價(jià)中的生殖毒性試驗(yàn)工作。

The importance and characteristics for the toxicity evaluation to reproduction and the developing fetus during the development of new medicines require a battery of the more complicated, elaborate and the higher technical tests than other toxicological studies. This article reviewed that step by step, attentions could be paid that concerns with the reproductive toxicity test in respects of the requirements of the technican’s genius, the preparations for the test, the observation of experimental stage, the records of the experiment, the dispensing and administer, the dissection and checking of the parent animals, and the communication with SD, many of which can play a vital role for the success of the reproductive and developmental study.