生殖毒性試驗是毒理學(xué)試驗中較為復(fù)雜和繁瑣、技術(shù)要求較高的試驗?，F(xiàn)從實驗技術(shù)人員資質(zhì)要求、試驗前準備、試驗期觀察、試驗記錄、供試品、對照品的配制和給予、親本動物的剖殺和檢查、與專題負責(zé)人溝通確認等方面介紹作為技術(shù)人員如何做好安全性評價中的生殖毒性試驗工作。

The importance and characteristics for the toxicity evaluation to reproduction and the developing fetus during the development of new medicines require a battery of the more complicated, elaborate and the higher technical tests than other toxicological studies. This article reviewed that step by step, attentions could be paid that concerns with the reproductive toxicity test in respects of the requirements of the technican’s genius, the preparations for the test, the observation of experimental stage, the records of the experiment, the dispensing and administer, the dissection and checking of the parent animals, and the communication with SD, many of which can play a vital role for the success of the reproductive and developmental study.