[關(guān)鍵詞]
[摘要]
腸吸收動(dòng)力學(xué)是決定口服藥物生物利用度的重要因素之一,在中藥口服制劑的開發(fā)及評價(jià)方面有著重要作用。評價(jià)藥物腸吸收動(dòng)力學(xué)的方法大致可分為3類:①體外試驗(yàn)法;②在體試驗(yàn)法;③體內(nèi)試驗(yàn)法。目前中藥腸吸收研究常用的實(shí)驗(yàn)方法為大鼠原位腸灌注模型、Caco-2細(xì)胞模型和血藥濃度法;研究熱點(diǎn)主要集中在黃酮類、皂苷類及生物堿等單一活性成分,而中藥整體或復(fù)方的研究甚少?,F(xiàn)介紹中藥腸吸收動(dòng)力學(xué)的主要研究方法,以及中藥腸吸收研究現(xiàn)狀,并對存在問題及其原因進(jìn)行了討論。
[Key word]
[Abstract]
Intestinal absorption kinetics is one of the critical influencing factors of the bioavailability of oral drugs and plays an important role in exploration and evaluation of oral preparation of Chinese materia medica (CMM). In principle, the methods of evaluating the intestinal absorption kinetics can be divided into three types. And now the common research methods in intestinal absorption of CMM are in situ perfusion model of rat, Caco-2 cells model, and drug plasma concentration test. Study hotspot primarily focus on single active ingredients, for example flavonoids, saponins, alkaloids and so on. However, studies on CMM as whole or compound medicines are rarely. The main methods and the research situation of intestinal absorption kinetics in CMM are reviewed, meanwhile some problems existed, reasons, and suggestions are discussed in this paper.
[中圖分類號]
[基金項(xiàng)目]
國家自然科學(xué)基金項(xiàng)目(30672651);四川省社會(huì)發(fā)展重大招標(biāo)項(xiàng)目(03SG011-010);成都市重點(diǎn)科技攻關(guān)項(xiàng)目(06GG2D992SF-039)