腸吸收動力學是決定口服藥物生物利用度的重要因素之一，在中藥口服制劑的開發(fā)及評價方面有著重要作用。評價藥物腸吸收動力學的方法大致可分為3類：①體外試驗法；②在體試驗法；③體內(nèi)試驗法。目前中藥腸吸收研究常用的實驗方法為大鼠原位腸灌注模型、Caco-2細胞模型和血藥濃度法；研究熱點主要集中在黃酮類、皂苷類及生物堿等單一活性成分，而中藥整體或復方的研究甚少?，F(xiàn)介紹中藥腸吸收動力學的主要研究方法，以及中藥腸吸收研究現(xiàn)狀，并對存在問題及其原因進行了討論。

Intestinal absorption kinetics is one of the critical influencing factors of the bioavailability of oral drugs and plays an important role in exploration and evaluation of oral preparation of Chinese materia medica (CMM). In principle, the methods of evaluating the intestinal absorption kinetics can be divided into three types. And now the common research methods in intestinal absorption of CMM are in situ perfusion model of rat, Caco-2 cells model, and drug plasma concentration test. Study hotspot primarily focus on single active ingredients, for example flavonoids, saponins, alkaloids and so on. However, studies on CMM as whole or compound medicines are rarely. The main methods and the research situation of intestinal absorption kinetics in CMM are reviewed, meanwhile some problems existed, reasons, and suggestions are discussed in this paper.

國家自然科學基金項目（30672651）；四川省社會發(fā)展重大招標項目（03SG011-010）；成都市重點科技攻關項目（06GG2D992SF-039）