2都相等這一假設(shè)下,提出一種識別最小有效劑量的逐步置信區(qū)間方法。而方差齊性假設(shè)條件通常是不合理的,本文主要利用 Stein 兩階段抽樣方法,給出方差無任何限制條件下識別最小有效劑量(MED)的逐步置信區(qū)間方法。;It is very important to be guaranteed that drug’s safety and efficiency to the mankind in Phase II and III clinical trials. Recently Hsu and Berger (1999) proposed a stepwise confidence interval method in dose-finding of minimum effective dose (MED) for dose-response study under equal variances. This is often in doubt. A new way to find MED was proposed by employing the Stein’s two-stage sampling method, the stepwise confidence procedure was proposed without any condition imposed on the variance. And the error rate is properly controlled."/>

醉酒后少妇被疯狂内射视频,一本色道久久综合一,在线天堂新版资源www在线下载,中文字幕乱人伦高清视频,中字幕视频在线永久在线观看免费

首頁 > 過刊瀏覽>2010年第33卷第1期 >2010,33(1):58-62. DOI:10.7501/j.issn.0253-6376.[year].1.[sequence]
上一篇 | 下一篇

識別藥物最小有效劑量的逐步方法

Stepwise confidence interval method for finding drug’s minimum effective dose in trial

發(fā)布日期:
您是第位訪問者
藥物評價(jià)研究 ® 2025 版權(quán)所有
技術(shù)支持:北京勤云科技發(fā)展有限公司
津備案:津ICP備13000267號 互聯(lián)網(wǎng)藥品信息服務(wù)資格證書編號:(津)-非經(jīng)營性-2015-0031