[關(guān)鍵詞]
[摘要]
目的:觀察新癀片外涂給藥的抗炎鎮(zhèn)痛作用。方法:制作炎癥及鎮(zhèn)痛模型,觀察新癀片外涂給藥的抗炎鎮(zhèn)痛作用。結(jié)果:新癀片外涂給藥對小鼠耳腫、大鼠角叉菜膠足腫、棉球肉芽腫等急、慢性炎癥有非常顯著的抑制作用;對大、小鼠水浴甩尾、小鼠醋酸扭體等溫?zé)岽碳?、化學(xué)刺激引起的疼痛有非常顯著的鎮(zhèn)痛作用,且在相同劑量下,外涂給藥和ig給藥的作用無明顯差異。結(jié)論:新癀片外涂給藥同ig給藥一樣,對各種腫痛均有較好的治療作用。
[Key word]
[Abstract]
Objective: To observe the anti-inflammation and analgesia effect of Xinhuang tablet by skin administration.Methods: Xinhuang tablet was observed in inflammation and analgesia model.Results: : Xinhuang tablet had very significant inhibition on acute and chronic inflammation and very significant analgesic effect on thermal and chemical stimulation, eg ear edema induced by croton oil in mice, paw swelling induced by carrageenin in rats, cotton pellet—induced granuloma in rats, writhing body response induced by acetic acid in mice and tail flicking in rats.And at the same doses, Xinhuang Tablet hadn't significant difference from ig administration. Conclusion: Skin administration as well as ig administration, Xinhuang Tablet had good therapeutic effect over the variety of swelling and pain.
[中圖分類號]
[基金項(xiàng)目]