目的：觀察丹參酮Ⅱ_A對(duì)阿霉素誘導(dǎo)2種腫瘤細(xì)胞（K562和Bel-7402細(xì)胞）死亡作用的影響。方法：MTT法檢測(cè)細(xì)胞存活率，Hoechst 33342染色從形態(tài)學(xué)上反映腫瘤細(xì)胞凋亡情況。結(jié)果：丹參酮Ⅱ_A本身對(duì)2種腫瘤細(xì)胞均有抑制增殖、促凋亡的作用，不會(huì)干擾阿霉素誘導(dǎo)腫瘤細(xì)胞死亡的作用，甚至對(duì)其對(duì)K562細(xì)胞的促凋亡作用有協(xié)同效果。結(jié)論：丹參酮Ⅱ_A對(duì)阿霉素抑制腫瘤細(xì)胞生長(zhǎng)有協(xié)同作用，但對(duì)腫瘤細(xì)胞有一定的選擇性。

Objective: To investigate the effects of TanshinoneⅡ_A on Adriamycin-induced suppression of growth in two kinds of tumor cell (K562 and Bel-7402). Methods: MTT colorimetric assay was used to detect the survival rate of tumor cells. Hoechst 33342 staining was used to reflect tumor cells apoptosis morphologically after different treatments. Results: Tanshinone II_A alone induced cell death in K562 cells and human hepatocarcinoma Bel-7402 cells. It did not interfere with the antiproliferative effects of Adriamycin in these two cells. When used with Adriamycin, Tanshinone II_A even enhanced cell death induced by Adriamycin in K562 cells. Conclusion: Tanshinone II_A showes synergistic effect with Adriamycin in suppression of tumor cells growth, however, with cell type specificity.