目的：利用基因芯片技術(shù)對復方丹參滴丸對心肌梗死大鼠基因表達的影響進行評價和研究。方法：使用冠脈結(jié)扎法造成大鼠心肌缺血模型，并提取給藥組和模型組大鼠心肌缺血區(qū)組織的總RNA，用大鼠全基因組芯片分析其基因組表達譜變化。結(jié)果：基因芯片結(jié)果顯示，與模型組相比，給藥組表達量發(fā)生變化的基因（Ratio＞2或＜0.5）有49條，其中表達下調(diào)的有39條，主要有Ppp3r1、Rhoa和Nppa，表達上調(diào)的有10條，包括H2-T24、RT1-CE15、Ptprb和Hcst等。結(jié)論：復方丹參滴丸可通過調(diào)節(jié)Wnt信號通路等多個基因和信號途徑來減小心肌梗死模型大鼠心臟缺血區(qū)的心肌損傷。

Objective: To investigate the role of traditional Chinese medicine Compound Danshen Dripping Pills in the regulation of immune-related genes expression in acute myocardial infarction. Methods: Myocardial infarction was induced by ligation of the left anterior descending artery. Isolated the total RNA from ischemia tissue of Compound Danshen Dripping Pills group and model group, and then screened the differently expressed genes with the gene chip technique. Results: There were 49 regulated genes by Compound Danshen Dripping Pills compared with the model, 39 genes were down-regulated, including Ppp3r1, Rhoa and Nppa; 10 genes were up-regulated such as H2-T24, RT1-CE15, Ptprb and Hcst. Conclusions: Some genes and signaling pathway such as Wnt signal pathway could be regulated to reduce the myocardial damage of ischemia tissue by Compound Danshen Dripping Pills.