腫瘤的多藥耐藥（multidrug resistance，MDR）是腫瘤化療失敗的主要原因之一。中草藥以其多成分，多作用機制的優(yōu)勢在我國腫瘤臨床治療方面獲得了廣泛的應(yīng)用，其中活血化瘀類中藥是常用的一類藥物，目前已經(jīng)發(fā)現(xiàn)該類中藥對腫瘤細(xì)胞的多藥耐藥具有逆轉(zhuǎn)作用?，F(xiàn)就MDR的發(fā)生機制和活血化瘀類中藥制劑逆轉(zhuǎn)MDR的研究作一綜述。

Multidrug resistance of tumors (MDR) is one of the main reasons for the failure of chemotherapy. Chinese herbal medicine was widely used in Chinese clinical cancer therapy because of its advantages of multi-component, multi-mechanism. The Blood Activating Stasis Removing Drugs of traditional Chinese medicine is commonly used, and its reversal activity on the tumor cells has been observed. In this review, the current research progress on the mechanism of multiple drug resistance and reversion by the Blood Activating Stasis Removing Drugs are described.

國家自然科學(xué)基金資助項目（30950014）；天津市應(yīng)用基礎(chǔ)與前沿技術(shù)研究計劃一般項目（08JCYBJC25900）