目的：探討甘草酸協(xié)同麻黃堿的平喘作用機(jī)制。方法：利用基于CHO細(xì)胞的β₂腎上腺素受體（β₂-AR）激動(dòng)藥活性評(píng)價(jià)體系，豚鼠離體氣管收縮和組胺引喘的活體動(dòng)物模型觀察甘草酸和麻黃堿聯(lián)用的協(xié)同平喘效果。結(jié)果：甘草酸自身不能引起離體氣管平滑肌舒張，平喘效果也不顯著，但與麻黃堿聯(lián)用可以通過提高β₂-AR的激動(dòng)效果，明顯增強(qiáng)平喘效果。結(jié)論：甘草酸通過調(diào)節(jié)β₂-AR信號(hào)通路增強(qiáng)麻黃堿的作用效果，兩者聯(lián)用有良好的協(xié)同作用。

Objective: To investigate the anti-asthmatic mechanism of combination of glycyrrhizic acid and ephedrine. Methods: With cell evaluating systems of β₂ adrenergic receptor (β₂-AR) agonists established by our laboratory, model of spasmolytic activities in vitro and antitussive activities in vivo, the effect of combination use of glycyrrhizic acid and ephedrine was observed. Results: In our study, glycyrrhizic acid alone showed little anti-asthmatic effect and could not relax the airway smooth muscles. However, it could enhance the anti-asthmatic activity of ephedrine when these two compounds were used together. Conclusion: Glycyrrhizic acid could increase bronchodilation activity of ephedrine through β₂-AR signal pathway and has synergistic effect on anti-asthmatic treatment.