2腎上腺素受體(β2-AR)激動(dòng)藥活性評(píng)價(jià)體系,豚鼠離體氣管收縮和組胺引喘的活體動(dòng)物模型觀察甘草酸和麻黃堿聯(lián)用的協(xié)同平喘效果。結(jié)果:甘草酸自身不能引起離體氣管平滑肌舒張,平喘效果也不顯著,但與麻黃堿聯(lián)用可以通過提高β2-AR的激動(dòng)效果,明顯增強(qiáng)平喘效果。結(jié)論:甘草酸通過調(diào)節(jié)β2-AR信號(hào)通路增強(qiáng)麻黃堿的作用效果,兩者聯(lián)用有良好的協(xié)同作用。;Objective: To investigate the anti-asthmatic mechanism of combination of glycyrrhizic acid and ephedrine. Methods: With cell evaluating systems of β2 adrenergic receptor (β2-AR) agonists established by our laboratory, model of spasmolytic activities in vitro and antitussive activities in vivo, the effect of combination use of glycyrrhizic acid and ephedrine was observed. Results: In our study, glycyrrhizic acid alone showed little anti-asthmatic effect and could not relax the airway smooth muscles. However, it could enhance the anti-asthmatic activity of ephedrine when these two compounds were used together. Conclusion: Glycyrrhizic acid could increase bronchodilation activity of ephedrine through β2-AR signal pathway and has synergistic effect on anti-asthmatic treatment."/> 2腎上腺素受體激動(dòng)藥;糖皮質(zhì)激素;ephedrine; glycyrrhizic acid; β2 adrenergic receptor (β2-AR) agonists; glucocorticoid"/>

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首頁(yè) > 過刊瀏覽>2010年第33卷第3期 >2010,33(3):183-186. DOI:10.7501/j.issn.0253-6376.[year].3.[sequence]
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甘草酸協(xié)同麻黃堿的平喘作用機(jī)制研究

Investigation of the anti-asthmatic mechanism of combination ofglycyrrhizic acid and ephedrine

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