0-180分別為346.05、455.74和1 655.14 μg/(mL·min),分布相半衰期t1/2α分別為103.90、15.59和9.49 min,消除相半衰期t1/2β分別為30 580.98、2 045.70和894.84 min。結(jié)論:iv給藥后,委陵菜黃酮血漿藥時曲線符合三室模型,在大鼠體內(nèi)迅速分布,但消除速率較慢。;Objective: To establish the method of measuring concentration of flavones from Potentilla chinensis in plasma of rats and to explore its pharmacokinetic features. Methods: An HPLC analysis method for the determination of flavones in P. chinensis was established and used to analyze the plasma concentration-time curve on iv injection of flavones in P. chinensis to rats. Results: A RP-HPLC analysis method with C-18 column for the determination of flavones in P. chinensis was established. After the injection of 10, 20, and 40 mg/kg of flavones in P. chinensis, the plasma concentration-time curve was in line with the three-compartment model, AUC0-180 were 346.05, 455.74, and 1 655.14 μg/(mL·min), respectively. Distribution phase half-life t1/2α was 103.90, 15.59, and 9.49 min, and elimination phase half-life t1/2β were 30 580.98, 2 045.70, and 894.84 min, respectively. Conclusion: After iv administration, the plasma concentration-time curve of flavones in P. chinensis is in line with the three-compartment model, the rapid distribution, while the slower rate of elimination in rats."/>

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首頁 > 過刊瀏覽>2010年第33卷第3期 >2010,33(3):187-190. DOI:10.7501/j.issn.0253-6376.[year].3.[sequence]
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委陵菜黃酮在大鼠體內(nèi)的藥動學研究

Pharmacokinetic study on flavones from Potentilla chinensis in rats in vivo

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