多藥耐藥（multidrug resistance，MDR）是目前造成腫瘤化療失敗的重要原因，尋找合適的MDR逆轉劑已成為腫瘤藥物學研究的關鍵性問題。國內學者進行了大量的工作，在中藥中篩選高效低毒的多藥耐藥逆轉劑?？偨Y了腫瘤多藥耐藥產生的經典機制及近年來中藥逆轉腫瘤多藥耐藥的研究進展。

Multiple drug resistance (MDR) of cancer cells is one of the main factors resulting in treatment failures, and therefore looking for suitable MDR reversal agents becomes the research emphasis on current cancer chemotherapy. The majority of scholars turns to Chinese herbal medicine following the failure of generations of reversal chemotherapy drugs. In this review, the current research progress on the mechanism of cancer cell MDR and the research situation of its reversion by Chinese herbal medicine are described.

國家自然科學基金資助項目（30950014），天津市應用基礎與前沿技術研究計劃一般項目（08JCYBJC25900）