目的：探討超聲量化技術(shù)評價大鼠肝臟脂肪變的價值。方法：大鼠ig酒精高脂乳液12周，制備脂肪肝模型。測量正常大鼠及模型大鼠肝臟二維聲像圖的灰度值，檢測肝組織三酰甘油（TG）、總膽固醇（TC），并將肝臟組織做病理切片，觀察肝細(xì)胞脂變情況。結(jié)果：與正常組比較，模型組超聲圖像近區(qū)、遠(yuǎn)區(qū)灰度顯著增加，肝臟TG、TC明顯升高。組織病理學(xué)分析可見模型大鼠肝臟典型脂肪樣變。結(jié)論：超聲量化技術(shù)可作為一種無創(chuàng)性量化方法用于判斷大鼠肝臟脂肪變化。

Objective: To explore the quantitive assessment of fatty liver of rats by measuring ultrasonic gray scale. Methods: A mixture composed of alcohol, lard and cholesterol was supplied to rats for 12 weeks in order to establish a rat model of hepatic steatosis. To measure ultrasonic gray scale of liver and hepatic pathological feature liver, and the changes of the contents of triglyeeride (TG) and cholesterol (TC) in liver tissue were observed. Results: Gray scale from near or far areas of ultrasonic image in model rats was higher than that of normal rats. And the rats of fatty liver diseases had a significantly higher level of TG, and TC in liver tissue than those of normal rats. The typical fatty liver pathologic changes were observed in the model rats. Conclusion: Hepatic ultrasonic gray scale can reflect the grades of hepatic steatosis, which is served as reliable noninvasive tools for the quantitative diagnosis of fatty liver disease.

國家新藥重大創(chuàng)制項目（2009zx09301-008）