[關(guān)鍵詞]
[摘要]
目的:介紹殼聚糖微/納米粒在新型定向給藥系統(tǒng)中的應(yīng)用,為發(fā)展安全高效的殼聚糖微/納米粒定向給藥系統(tǒng)提供參考。方法:綜合近年來出版的有關(guān)文獻,對殼聚糖基本性質(zhì),定位給藥于各組織部位進行了探討。結(jié)果:殼聚糖微/納米??蓱?yīng)用于腦、眼、鼻、口、肺、胃、小腸、結(jié)腸等器官靶向給藥。結(jié)論:殼聚糖微/納米粒作為一種新型藥用輔料,在定位給藥系統(tǒng)中已經(jīng)得到了開發(fā)和應(yīng)用。
[Key word]
[Abstract]
Objective: Chitosan micro / nano particles in novel targeted drug delivery system were reviewed to provide reference in development of safe and efficient chitosan micro / nano particles targeting drug delivery system. Methods: According to the literature published in the recent years, the basic nature of chitosan and it’s targeted drug delivery in various tissues were discussed. Results: Chitosan micro / nano particles can be applied to brain, ophthalmic, nasal, buccal, pulmonary, stomach, small intestine, colon and other organs targeted drug delivery. Conclusion: Chitosan micro / nano particles, as a kind of novel pharmaceutical excipient, have been developed and applied in targeted drug delivery system.
[中圖分類號]
[基金項目]