目的：介紹殼聚糖微／納米粒在新型定向給藥系統(tǒng)中的應(yīng)用，為發(fā)展安全高效的殼聚糖微／納米粒定向給藥系統(tǒng)提供參考。方法：綜合近年來出版的有關(guān)文獻，對殼聚糖基本性質(zhì)，定位給藥于各組織部位進行了探討。結(jié)果：殼聚糖微／納米?？蓱?yīng)用于腦、眼、鼻、口、肺、胃、小腸、結(jié)腸等器官靶向給藥。結(jié)論：殼聚糖微／納米粒作為一種新型藥用輔料，在定位給藥系統(tǒng)中已經(jīng)得到了開發(fā)和應(yīng)用。

Objective: Chitosan micro / nano particles in novel targeted drug delivery system were reviewed to provide reference in development of safe and efficient chitosan micro / nano particles targeting drug delivery system. Methods: According to the literature published in the recent years, the basic nature of chitosan and it’s targeted drug delivery in various tissues were discussed. Results: Chitosan micro / nano particles can be applied to brain, ophthalmic, nasal, buccal, pulmonary, stomach, small intestine, colon and other organs targeted drug delivery. Conclusion: Chitosan micro / nano particles, as a kind of novel pharmaceutical excipient, have been developed and applied in targeted drug delivery system.