腦心清片對腦動(dòng)脈硬化具有良好的防治效果。近十多年國內(nèi)外對腦心清片防治腦動(dòng)脈硬化的臨床、藥理作用及其物質(zhì)基礎(chǔ)的廣泛研究表明，腦心清片含有黃酮、有機(jī)酸和香豆素類等化學(xué)活性成分，腦心清片及其活性成分能降血壓，降血脂，改善血液流變性，抑制血管內(nèi)皮增生，抑制血小板聚集；調(diào)節(jié)免疫功能和抑制淋巴細(xì)胞與神經(jīng)細(xì)胞的粘附，抑制炎癥反應(yīng)，改善神經(jīng)細(xì)胞氧化還原狀態(tài)，上調(diào)抗氧化基因表達(dá)，抗氧化清除自由基，抑制脂質(zhì)過氧化，減輕缺血腦組織自由基損傷；此外，還能調(diào)節(jié)鈣離子穩(wěn)態(tài)，抗興奮性谷氨酸毒性，抑制神經(jīng)細(xì)胞凋亡和腦水腫，保護(hù)缺血腦組織抗腦缺血損傷；保護(hù)神經(jīng)組織并促進(jìn)神經(jīng)細(xì)胞功能恢復(fù)等多方面、多層次、多靶點(diǎn)作用來阻斷腦動(dòng)脈硬化發(fā)生發(fā)展，從而發(fā)揮良好的防治腦動(dòng)脈硬化癥作用。

Naoxinqing (NXQ, only made from Leaves of Diospyros kaki by Hutchison Whampoa Guangzhou Baiyunshan Chinese Medicine Co. Ltd, Guangzhou) is a patented and approved drug of Traditional Chinese Medicine (TCM) used for the treatment of Cerebral Arteriosclerosis (CeA). Much significant progress has been achieved in the extensive studies on the mechanism of NXQ effect of the prevention and treatment for Cerebral Arteriosclerosis. It is found that NXQ and its flavonoids components showed significant anti-Cerebral Arteriosclerosis and neuroprotection against ischemia / reperfusion injury in vivo and in vitro. NXQ might lower serum level of lipid (TC, TG, LDL-C) and inhibit vascular endothelial proliferation, improve blood rheology, and inhibit platelet aggregation. NXQ could protect neuronal cells from injuries induced by hypoxia & serum deprivation / recover, by oxidative stress, or by excito-toxic glutamate. Regulating immune function, inhibiting inflammation, improving the redox desequilibrium, up-regulating the anti-oxydative gene bcl-2 and activating the activity of L-type Ca²⁺ channel in Susceptible Neuron as well as inhibiting adhesion between lymphocytes and DRG might be responsible for the beneficial effects for Naoxinqing use in the treatment of Cerebral Arteriosclerosis. Flavonoids should be key and effective constituents of NXQ.