藥物轉運體在藥代動力學方面起到非常重要的作用，它與藥物的吸收、分布、排泄、藥效發(fā)揮、以及藥物毒性作用等密切相關。基于轉運體的藥物間相互作用，還能影響到臨床合并治療藥物之間的藥代動力學關系。本研究室已經建立了一整套的實用于藥代動力學研究和藥物間相互作用評價，高效表達人藥物轉運體蛋白的體外篩選系統(tǒng)，并已將其應用于新藥的篩選研究。此方法的特點在于，以表達人藥物轉運體蛋白的宿主培養(yǎng)細胞為研究對象，在臨床前期提供與臨床試驗相似的研究結果，今后必將成為藥物研發(fā)領域有用的評價方法。

Drug transporters play an important role in the pharmacokinetics. It is closely related to drug absorption, distribution, elimination, efficacy, and toxicity. And it can also affect the clinical pharmacokinetics by transporter-based drug interactions in the clinical combination therapy. In our laboratory, the high throughput drug transporter screening systems for estimation of human pharmacokinetics and drug-drug interaction were established and have been already applied to the study on drug discovery. In which, cultured cell models expressing human transporter genes are mainly used and should be very useful in the field of drug discovery and development.