[關(guān)鍵詞]
[摘要]
藥物轉(zhuǎn)運(yùn)體在藥代動(dòng)力學(xué)方面起到非常重要的作用,它與藥物的吸收、分布、排泄、藥效發(fā)揮、以及藥物毒性作用等密切相關(guān)?;谵D(zhuǎn)運(yùn)體的藥物間相互作用,還能影響到臨床合并治療藥物之間的藥代動(dòng)力學(xué)關(guān)系。本研究室已經(jīng)建立了一整套的實(shí)用于藥代動(dòng)力學(xué)研究和藥物間相互作用評(píng)價(jià),高效表達(dá)人藥物轉(zhuǎn)運(yùn)體蛋白的體外篩選系統(tǒng),并已將其應(yīng)用于新藥的篩選研究。此方法的特點(diǎn)在于,以表達(dá)人藥物轉(zhuǎn)運(yùn)體蛋白的宿主培養(yǎng)細(xì)胞為研究對(duì)象,在臨床前期提供與臨床試驗(yàn)相似的研究結(jié)果,今后必將成為藥物研發(fā)領(lǐng)域有用的評(píng)價(jià)方法。
[Key word]
[Abstract]
Drug transporters play an important role in the pharmacokinetics. It is closely related to drug absorption, distribution, elimination, efficacy, and toxicity. And it can also affect the clinical pharmacokinetics by transporter-based drug interactions in the clinical combination therapy. In our laboratory, the high throughput drug transporter screening systems for estimation of human pharmacokinetics and drug-drug interaction were established and have been already applied to the study on drug discovery. In which, cultured cell models expressing human transporter genes are mainly used and should be very useful in the field of drug discovery and development.
[中圖分類號(hào)]
[基金項(xiàng)目]