目的：探討射干抗炎的藥效物質(zhì)基礎(chǔ)。方法：采用SPSS統(tǒng)計(jì)分析方法，以41個(gè)色譜峰的相對(duì)峰面積為自變量，提取物對(duì)蛋清致大鼠足跖腫脹形成的抑制作用為因變量進(jìn)行相關(guān)分析和回歸分析，并進(jìn)行了初步時(shí)效學(xué)觀察。結(jié)果：得到41個(gè)色譜峰的相關(guān)系數(shù)，0.5 h時(shí)，消炎效果最好。結(jié)論：初步確定11個(gè)色譜峰所代表的化學(xué)組分為射干抗炎的藥效物質(zhì)基礎(chǔ)，其中X₃₃為鳶尾黃素，其余為未知成分，時(shí)效學(xué)實(shí)驗(yàn)結(jié)果提示，射干抗炎作用起效較快，但作用時(shí)間較短。

Objective: To study the anti-inflammatory therapeutic material basis of Belamcanda chinensis. Methods: Using SPSS statistical analysis methods to 41 peaks of the relative peak area of the independent variables, extract on egg white-induced mice paw edema formation inhibition as the dependent variable for correlation analysis and regression analysis. Results: Each correlation coefficient of 40 chromatographic peaks is got，the effect of antiphlogistic is the best at 0.5 h. Conclusion: It can be preliminary determined that the 11 chromatographic peaks represented by the chemical constituent for Leontopodium have an acute anti-inflammatory pharmacodynaic material basis, which chromatographic peak that X33 is Iris flavin, and the remaining peaks are the unknown components. It suggests that the effect of antiphlogistic was quick but the effecting time was short.

科技部重大專(zhuān)項(xiàng)“十一·五”重大新藥創(chuàng)制（2009ZX09103-330）