目的：研究大鼠sc PTH（1-34）的藥動學(xué)特征。方法：用¹²⁵I標(biāo)記PTH（1-34）示蹤法對大鼠sc PTH（1-34）后的血清藥物濃度進(jìn)行了測定，并用3P97程序擬和分析并計(jì)算藥動學(xué)參數(shù)，采用超濾離心的方法進(jìn)行藥物與血漿蛋白結(jié)合率的研究。結(jié)果：大鼠sc PTH（1-34）10、20和40 μg/kg后，藥物消除符合一房室模型。平均t_1/2ke為（0.92±0.04）h；平均CL為（0.56±0.05）L/（kg·h）；C_max和AUC_{0-8 h}均與劑量呈線性正相關(guān)，不同劑量藥物與血漿蛋白平均結(jié)合率為13.4％。結(jié)論：大鼠sc PTH（1-34）后，藥物消除符合線性動力學(xué)特征。

Objective: To study the pharmacokinetic characteristics on parathyroid hormone (PTH, 1-34) after sc injection in rats. Methods: Serum drug concentration was measured by ¹²⁵I labeled method after sc injection in rats, the pharmacokinetic model and parameters were fitted and calculated by the 3P97 program. Results: After sc injection at doses of 10, 20, and 40 μg/kg in rats, the serum drug concentration-time curve was fitted to a one-compartment model. Mean t_1/2ke was (0.92 ± 0.04) h and mean CL was (0.56 ± 0.05) L/(kg·h). The C_max and AUC_{0-8 h} were positive linear correlation with the dose. Mean binding ratio of various doses drug with plasma protein was 13.4%. Conclusion: After sc injection of PTH (1-34) to rats, the elimination of PTH (1-34) could fit to the linear kinetics.

國家科技支撐計(jì)劃（2007BAI14IB04）