125I標(biāo)記PTH(1-34)示蹤法對(duì)大鼠sc PTH(1-34)后的血清藥物濃度進(jìn)行了測(cè)定,并用3P97程序擬和分析并計(jì)算藥動(dòng)學(xué)參數(shù),采用超濾離心的方法進(jìn)行藥物與血漿蛋白結(jié)合率的研究。結(jié)果:大鼠sc PTH(1-34)10、20和40 μg/kg后,藥物消除符合一房室模型。平均t1/2ke為(0.92±0.04)h;平均CL為(0.56±0.05)L/(kg·h);Cmax和AUC0-8 h均與劑量呈線性正相關(guān),不同劑量藥物與血漿蛋白平均結(jié)合率為13.4%。結(jié)論:大鼠sc PTH(1-34)后,藥物消除符合線性動(dòng)力學(xué)特征。;Objective: To study the pharmacokinetic characteristics on parathyroid hormone (PTH, 1-34) after sc injection in rats. Methods: Serum drug concentration was measured by 125I labeled method after sc injection in rats, the pharmacokinetic model and parameters were fitted and calculated by the 3P97 program. Results: After sc injection at doses of 10, 20, and 40 μg/kg in rats, the serum drug concentration-time curve was fitted to a one-compartment model. Mean t1/2ke was (0.92 ± 0.04) h and mean CL was (0.56 ± 0.05) L/(kg·h). The Cmax and AUC0-8 h were positive linear correlation with the dose. Mean binding ratio of various doses drug with plasma protein was 13.4%. Conclusion: After sc injection of PTH (1-34) to rats, the elimination of PTH (1-34) could fit to the linear kinetics."/> 125I標(biāo)記;藥動(dòng)學(xué);蛋白結(jié)合;recombinant human parathyroid hormone analogue (PTH, 1-34); 125I labled; pharmacokinetics; protein binding"/>

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首頁(yè) > 過(guò)刊瀏覽>2010年第33卷第6期 >2010,33(6):409-412. DOI:10.7501/j.issn.0253-6376.[year].6.[sequence]
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重組人甲狀旁腺素類似物PTH(1-34)在大鼠體內(nèi)藥動(dòng)學(xué)研究

In vivo pharmacokinetics of recombinant human parathyroid hormone analogue in rats

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