目的：用骨髓微核試驗(yàn)觀察莧菜紅對小鼠的毒性反應(yīng)，為進(jìn)一步致突變研究提供參考。方法：試驗(yàn)動物隨機(jī)分5組，分別為陰性對照組，莧菜紅低、中、高3個(gè)劑量組和陽性對照組。每組10只動物，雌雄各5只。連續(xù)ig給予不同劑量的莧菜紅，觀察試驗(yàn)期內(nèi)小鼠的一般毒性癥狀、體質(zhì)量增長情況和骨髓細(xì)胞微核率的改變。結(jié)果：實(shí)驗(yàn)期間動物的精神、外觀均無異常。莧菜紅高劑量組動物體質(zhì)量在給藥第2～3天下降，中、低劑量組動物體質(zhì)量未見異常。莧菜紅劑量在500～2 000 mg/kg對小鼠骨髓微核率無明顯影響。結(jié)論：莧菜紅對小鼠骨髓細(xì)胞無明顯致突變作用。

Objective: Observing toxic reaction and calculating micronucleus rate of mice administrated by different doses of amaranth red to provide a reference for further mutagenesis studies. Methods: The experimental animals were randomly divided into five groups such as negative control group, amaranth red low-, meddle-, and high-dose groups, and positive control group, respectively. Ten animals were in each group, male and female. By continous ig administration, the general toxicity, body weight growth, and bone marrow cell micronucleus in mice were observed during the experimental period. Results: No abnormal reactions in animal mind and appearance were observed. The growth of body weight in high-dose group decreased in days 2－3 after administration, while the animals in low- and middle-dose groups showed normal body weight. Amaranth red within the dose of 500—2 000 mg/kg did not significantly affect the mouse bone marrow micronucleus rate. Conclusion: Amaranth red has no significant mutagenicity on mouse bone marrow cells.

中國檢驗(yàn)檢疫科學(xué)研究院基本科研業(yè)務(wù)費(fèi)專項(xiàng)資金資助項(xiàng)目（2008JK001），國家質(zhì)量監(jiān)督檢驗(yàn)檢疫總局課題（2009IK310、2008IK133）