目的：制備姜黃素（Cur）固體脂質(zhì)納米粒（SLN）。方法：用薄膜超聲法制備Cur-SLN，以m_cur︰m_{單硬脂酸甘油酯}、m_{單硬脂酸甘油酯}︰m_卵磷脂、聚山梨酯-80質(zhì)量濃度、超聲時(shí)間為考察因素，以包封率為指標(biāo)，用正交試驗(yàn)優(yōu)選處方，并考察其粒徑分布、Zeta電位。結(jié)果：當(dāng)m_cur︰m_{單硬脂酸甘油酯}=1︰3、m_{單硬脂酸甘油酯}︰m_卵磷脂=1︰2.5、聚山梨酯-80質(zhì)量濃度2.5%、超聲時(shí)間12 min時(shí)，所制得的Cur-SLN平均粒徑為（145.6±5）nm，Zeta電位為（－31.9±1.5）mV，包封率為（97.42±0.39）%，載藥量為(7.92 ± 0.05)%。結(jié)論：采用薄膜-超聲法制備Cur-SLN可行，為開(kāi)發(fā)姜黃素新型給藥系統(tǒng)提供試驗(yàn)依據(jù)。

Objective: To optimize technique for preparing curcumin solid lipid nanoparticles (Cur-SLN) by film-ultrasonic dispersion. Methods: The influences of various factors，such as the ratios of curcumin and monostearin, monostearin and lecithin. Taking the concentration of Tween-80 and ultrasonic time (min) as on factors and the entrapment efficiency as index, the optimum formula was selected and particle size distribution and Zeta potential were studied by orthogonal test. Results: The optimized preparation conditions were as follows: m_cur-m_monostearin = 1︰3; m_{monostearin -}m_lecithin = 1︰2.5; The concentration of Tween-80 was 2.5%; Ultrasonic time was 12 min. The average particle size diameter was (145.6 ± 5) nm; Zeta potential was (?31.9 ± 1.5) mV; Entrapment efficiency was (97.42 ± 0.39) %; Drug loading was (7.92 ± 0.05)%. Conclusion: It is feasible to prepare Cur-SLN by film-ultrasonic dispersion techniques and the study results provide the test evidence for developing new curcumine drug delivery system.