自胰島素首次用于治療糖尿病以來，隨著對(duì)糖尿病病理生理和發(fā)病機(jī)制認(rèn)識(shí)的深入，胰島素的應(yīng)用越來越廣泛。綜述近年來相關(guān)文獻(xiàn)中有關(guān)胰島素及其類似物制劑的分類、給藥途徑、體內(nèi)吸收代謝、臨床應(yīng)用和不良反應(yīng)等方面內(nèi)容，為進(jìn)一步研究、開發(fā)和合理利用胰島素及其類似物提供參考。

Since the first time insulin used in the treatment of diabetes, and with the development of pathophysiology and pathogenesis in diabetes, insulin has been gaining a widely usage. For the future research, development and rational utilization of insulin, this paper reviews recent literature relating to classification, administrations, absorption, metabolism, clinical applications, adverse reactions of insulin and its analogues.

國家科技支撐計(jì)劃項(xiàng)目（2007BAI41B04），“重大新藥創(chuàng)制”科技重大專項(xiàng)（2008ZX09305-005），天津創(chuàng)新藥物安全評(píng)價(jià)技術(shù)平臺(tái)建設(shè)