綜述石杉堿甲的研究進(jìn)展，分別從作用機(jī)制、藥理作用、合成以及結(jié)構(gòu)修飾等方面對石杉堿甲的研究進(jìn)行總結(jié)，并簡述其發(fā)展方向：ZT-1作為石杉堿甲的替代物，已經(jīng)在歐洲完成Ⅱ期臨床，有望成為我國具有自主知識(shí)產(chǎn)權(quán)，又有希望打入國際市場的創(chuàng)新藥物。

The research and development of huperzine A are summarized separately by its mechanism, pharmacology, synthesis, and the structure modification and its development direction is outlined in this paper. ZT-1 as a substitute of huperzine A, the Phase II trial in clinic has been completed in Europe. Huperzine A as an innovation drug is expected to enter the international market with the Chinese intellectual property.