目的 比較常用的國產(chǎn)與進口銀杏葉片中所含萜類內(nèi)酯，以保證臨床用藥的有效性。方法 采用Ultimate 3000高效液相色譜儀結(jié)合蒸發(fā)光散射檢測器，Zorbax SB-C₁₈柱（250 mm×4.6 mm，5 μm），以正丙醇-四氫呋喃-水（1∶15∶84）為流動相，體積流量1.0 mL/min，漂移管溫度115 ℃，壓縮氣體氮氣體積流量為3.00 L/min，檢測國產(chǎn)和進口2種銀杏葉片各3批所含銀杏內(nèi)酯A、B、C和白果內(nèi)酯的量，并計算內(nèi)酯總量。結(jié)果/b> 2種銀杏葉片每片所含銀杏內(nèi)酯A、B、C和白果內(nèi)酯分別為（1.29±0.05）、（0.69±0.05），（0.83±0.17）、（0.45±0.09）mg，（0.45±0.05）、（0.46±0.02），（1.38±0.15）、（1.26±0.06）mg，內(nèi)酯總量分別為（3.95±0.11）、（2.87±0.22）mg。結(jié)論 2種銀杏葉片所含萜類內(nèi)酯的量均符合中國藥典的規(guī)定，其中二者所含銀杏內(nèi)酯C和白果內(nèi)酯的量相似，但國產(chǎn)銀杏葉片所含銀杏內(nèi)酯A、B的量以及內(nèi)酯總量明顯高于進口銀杏葉片。

Objective Comparing the contents of triterpene lactones in two kinds (domestic and imported) of Ginkgo biloba Tablets commonly used in the hospital, so as to ensure the clinical efficacy. Methods An HPLC-ELSD method was employed to determine the contents of ginkgolide A, B, C, bilobalide and the total triterpene lactones in three lots of Chinese and imported Ginkgo biloba Tablets. The analysis was performed on Zorbax SB-C₁₈ column (250 mm × 4.6 mm，5 μm) with n-propanol - tetrahydrofuran - water (1 : 15 : 84) as mobile phase at a flow rate of 1.0 mL/min. The drift tube temperature of the ELSD Detector was 115 ℃ and the evaporative gas was nitrogen at speed of 3.00 L/min. Results The contents of ginkgolide A, B, C, and bilobalide in three lots of domestic and imported Ginkgo biloba Tablets were (1.29 ± 0.05), and (0.69 ± 0.05); (0.83 ± 0.17), and (0.45 ± 0.09) mg; (0.45 ± 0.05), and (0.46 ± 0.02), (1.38 ± 0.15), and (1.26 ± 0.06) mg per tablet; The total contents of lactones were (3.95 ± 0.11) and (2.87 ± 0.22) mg, respectively. Conclusion Contents of terpene lactones in domestic and imported Ginkgo biloba Tablets are both qualified in accordance with Pharmacopoeia of People’s Republic of China; And the two kinds of tablets have similar contents of ginkgolide C and bilobalide, but the contents of ginkgolide A, B and total terpene lactones in domestic Ginkgo biloba Tablet are obviously more than those in imported Ginkgo biloba Tablet.

基金項目：國家973資助項目（2005CB523400）