目的 觀察復(fù)方野馬追膠囊對(duì)呼吸道合胞病毒（RSV）感染及炎性因子IL-8釋放的抑制作用。方法 采用細(xì)胞病變（CPE）觀察和活細(xì)胞染色方法，觀察復(fù)方野馬追膠囊對(duì)呼吸道合胞病毒感染細(xì)胞的保護(hù)。同時(shí)，通過(guò)ELISA法測(cè)定培養(yǎng)上清IL-8的變化。結(jié)果 復(fù)方野馬追膠囊對(duì)呼吸道合胞病毒感染有抑制作用，其中以治療法效果最為明顯。同時(shí)該藥對(duì)呼吸道合胞病毒感染后引起的IL-8釋放也有明顯抑制作用。結(jié)論 復(fù)方野馬追膠囊具有明顯的體外抗呼吸道合胞病毒感染、降低感染后氣道炎癥因子釋放的作用。

Objective To observe the inhibition of Fufang Yemazhui Capsula on respiratory syncytial virus (RSV) infection and the release of inflammatory factors IL-8. Methods Cytopathic effect (CPE) observation and living cells staining were employed to investigate the protection of Fufang Yemazhui Capsula to the infected cells. ELISA was used to detect the concentration of IL-8. Results Fufang Yemazhui Capsula obviously inhibited the RSV infection, especially after viral infection. And it also could significantly inhibit the release of IL-8 in RSV-infected A549 cells. Conclusion Fufang Yemazhui Capsula shows the significant antiviral effect in vitro and takes a role in controlling the release of airway inflammatory factors of RSV infection.

江蘇省國(guó)際科技合作計(jì)劃項(xiàng)目（BZ2007063）。