50)>5.0 g/kg,表明納米銀溫敏噴霧凝膠的急性毒性較低。納米銀溫敏噴霧凝膠質(zhì)量濃度低于7.0 μg/mL時(shí),對(duì)細(xì)胞的生長(zhǎng)無(wú)明顯抑制作用,但隨著劑量的加大和作用時(shí)間的延長(zhǎng),對(duì)細(xì)胞生長(zhǎng)的抑制作用越來(lái)越明顯,并有一定的劑量依賴趨勢(shì),同時(shí)細(xì)胞在形態(tài)學(xué)上也出現(xiàn)了一系列變化。結(jié)論 納米銀溫敏噴霧凝膠無(wú)明顯毒性。;Objective To evaluate the toxicity of temperature-sensitive spray gel containing silver nanoparticles which was used for the treatment of women bacterial vaginosis. Methods The acute toxicity study was conducted using main test of up-and-down procedure. The cytotoxicity of this agent on rat’s fibroblast L-929 cells was examined with MTT method. MTT assay was performed to observe the toxicity of temperature-sensitive spray gel containing silver nanoparticles in different dose levels and to evaluate the cell proliferation. The morphologic changes of the cells were observed by inverted microscope. Results The study demonstrated that LD50 value was above 5 000 mg/kg, which showed low acute toxicity of this gel. No significant inhibitive effect on the growth of L-929 cells was observed from inverted microscopy when the concentration of gel was less than 7.0 μg/mL. With increasing dose levels of temperature-sensitive spray gel containing silver nanoparticles and longer interaction time between this agent and L-929 cells, the inhibitive effect on the growth of L-929 cells was increased and showed the tendency of dose dependent. Meanwhile, the morphologic changes of the cells were significant. Conclusion No significant toxicity in vivo and in vitro is found in temperature-sensitive spray gel containing silver nanoparticles."/>

醉酒后少妇被疯狂内射视频,一本色道久久综合一,在线天堂新版资源www在线下载,中文字幕乱人伦高清视频,中字幕视频在线永久在线观看免费

首頁(yè) > 過刊瀏覽>2011年第34卷第3期 >2011,34(3):174-178. DOI:10.7501/j.issn.0253-6376.[year].3.[sequence]
上一篇 | 下一篇

納米銀溫敏噴霧凝膠的毒性試驗(yàn)研究

Toxicity of temperature-sensitive spray gel containing silver nanoparticles

發(fā)布日期:
您是第位訪問者
藥物評(píng)價(jià)研究 ® 2025 版權(quán)所有
技術(shù)支持:北京勤云科技發(fā)展有限公司
津備案:津ICP備13000267號(hào) 互聯(lián)網(wǎng)藥品信息服務(wù)資格證書編號(hào):(津)-非經(jīng)營(yíng)性-2015-0031