Objective To develop a gas chromatography method for the determination of residual organic solvents in Moxifloxacin. Methods The samples were injected into INNOWAX capillary column and analyzed with FID detector using acetonitrile as the internal standard. Results The linear ranges of ethyl ether, methanol, and DMF were 50—800 μg/mL (r = 0. 999 8), 30—480 μg/mL (r = 0. 999 9), and 8.8—140. 8 μg/mL (r = 0. 999 6), respectively. The recoveries were 99.71%, 100.30%, and 99.54%; RSD were 1.87%, 1.32%, and 1.67%, respectively (n = 9). Conclusion The method is simple, accurate, and sensitive with good reproducibility. It can be used for the determination of the residual organic solvents in Moxifloxacin."/>